Frisman E V, Kas'ianenko N A
Mol Biol (Mosk). 1990 Mar-Apr;24(2):318-27.
The hydrodynamic and optical properties (intrinsic viscosity and optical anisotropy of DNA) have been studied at the high ionic strength mu greater than or equal to 1 M. It has been shown that the effective volume of DNA molecule doesn't depend of mu when mu greater than or equal to 1 M. In these conditions the electrostatical interactions in DNA disappear. But thermodynamic excluded volume effects do not depend on mu and play also an important role in this range of mu (mu greater than or equal to 1 M). It has been concluded that the condensation of DNA in solutions of high salt concentration is the result of local denaturation of DNA. It has been shown that the optical anisotropy of DNA increases drastically at mu congruent to 2 M but the persistence length of DNA does not change under these conditions.
在高离子强度μ≥1M的条件下，研究了DNA的流体动力学和光学性质（特性粘度和光学各向异性）。结果表明，当μ≥1M时，DNA分子的有效体积不依赖于μ。在这些条件下，DNA中的静电相互作用消失。但热力学排除体积效应不依赖于μ，并且在该μ范围（μ≥1M）中也起着重要作用。得出的结论是，高盐浓度溶液中DNA的凝聚是DNA局部变性的结果。结果表明，当μ≈2M时，DNA的光学各向异性急剧增加，但在这些条件下DNA的持久长度不变。
