New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA.
J Clin Endocrinol Metab. 2013 Jun;98(6):2442-50. doi: 10.1210/jc.2012-2582. Epub 2013 Apr 26.
Previous studies indicate that testosterone (T) is positively correlated with lean mass and inversely correlated with fat mass in men; however, the directionality of these associations, as well as the association with other hormones including estradiol (E2) and SHBG, is unclear.
We examined cross-sectional and longitudinal associations of E2, T, SHBG, and E2/T ratio with body composition among men ages 30 to 79 in the Boston Area Community Health/Bone Survey. Total, trunk, and appendicular lean and fat mass were measured by dual-energy x-ray absorptiometry at baseline, and weight and waist/hip circumference were measured at baseline and follow-up. Partial Pearson correlation coefficients were used to estimate the linear relationship between each body composition measure and log-transformed hormone variable.
In cross-sectional analyses of 821 men, T, calculated free T, and SHBG were inversely correlated with fat mass, weight, body mass index, waist/hip circumference, and waist-to-hip ratio, with multivariable-adjusted correlations ranging from -0.13 to -0.37. Calculated free E2 was positively correlated with percentage total (r = .13) and trunk (r = .15) fat mass, and E2/T was positively correlated with all measures examined (r = .13-.40). There were no significant multivariable-adjusted longitudinal associations between baseline hormone levels and change in weight, body mass index, waist/hip circumference, or waist-to-hip ratio after an average follow-up of 4.8 years.
We observed significant cross-sectional associations between hormone levels, including E2, T, and E2/T, and body composition measures in men. Longitudinal analyses showing no influence of baseline hormone levels on change in anthropometric measures imply that body composition affects hormone levels and not the reverse.
先前的研究表明，男性的睾丸酮（T）与瘦体重呈正相关，与脂肪量呈负相关；然而，这些关联的方向性，以及与包括雌二醇（E2）和性激素结合球蛋白（SHBG）在内的其他激素的关联，尚不清楚。
我们研究了 30 至 79 岁的波士顿地区社区健康/骨骼调查男性中 E2、T、SHBG 和 E2/T 比值与身体成分的横断面和纵向关联。基线时通过双能 X 射线吸收法测量全身、躯干和四肢的瘦体重和脂肪量，在基线和随访时测量体重和腰围/臀围。采用偏 Pearson 相关系数估计每个身体成分测量值与对数转换后的激素变量之间的线性关系。
在 821 名男性的横断面分析中，T、计算游离 T 和 SHBG 与脂肪量、体重、体重指数、腰围/臀围和腰臀比呈负相关，多变量调整后的相关系数范围为-0.13 至-0.37。计算游离 E2 与全身（r = 0.13）和躯干（r = 0.15）脂肪百分比呈正相关，E2/T 与所有检查的指标呈正相关（r = 0.13-0.40）。在平均随访 4.8 年后，基线激素水平与体重、体重指数、腰围/臀围或腰臀比的变化之间没有显著的多变量调整后的纵向关联。
我们观察到激素水平，包括 E2、T 和 E2/T，与男性身体成分测量值之间存在显著的横断面关联。纵向分析显示，基线激素水平对人体测量指标变化没有影响，这意味着身体成分影响激素水平，而不是相反。
