Institute of Social and Preventive Medicine, University of Zurich, Hirschengraben 84, 8001, Zürich, Switzerland.
Cancer Causes Control. 2011 Aug;22(8):1141-51. doi: 10.1007/s10552-011-9790-z. Epub 2011 Jun 16.
Obesity is associated with a variety of chronic diseases, including cancer, which may partly be explained by its influence on sex steroid hormone concentrations. Whether different measures of obesity, i.e., body mass index (BMI), waist circumference, and percent body fat were differentially associated with circulating levels of sex steroid hormones was examined in 1,265 men, aged 20-90+ years old, attending the morning examination session of the Third National Health and Nutrition Examination Survey (NHANES III).
Serum hormones were measured by immunoassay. Weight, height, and waist circumference were measured by trained staff. Percent body fat was estimated from bioelectrical impedance. Multivariate linear regression was used to estimate associations between body fatness measures and hormone levels.
Total and free testosterone and sex hormone binding globulin concentrations decreased, whereas total and free estradiol increased with increasing BMI, waist circumference, and percent body fat (all p trend < 0.05). The magnitude of change in these hormones was similar for a one-quartile increase in each body fatness measure.
Measured BMI, waist circumference, and percent body fat led to similar inferences about their association with hormone levels in men.
肥胖与多种慢性疾病有关，包括癌症，其部分原因可能是它对性激素浓度的影响。本研究旨在探讨不同肥胖指标（体重指数[BMI]、腰围和体脂百分比）与男性循环性激素水平的相关性。共纳入 1265 名 20-90 岁参加第三次全国健康和营养调查（NHANES III）晨检的男性。
采用免疫测定法检测血清激素，由经过培训的工作人员测量体重、身高和腰围，通过生物电阻抗法估计体脂百分比。采用多元线性回归估计肥胖指标与激素水平之间的关系。
BMI、腰围和体脂百分比增加时，总睾酮、游离睾酮和性激素结合球蛋白浓度降低，而总雌二醇和游离雌二醇浓度增加（所有 p 趋势<0.05）。每个肥胖指标增加一个四分位数时，这些激素的变化幅度相似。
在男性中，BMI、腰围和体脂百分比的测量值对其与激素水平的相关性得出了相似的结论。
