源于着色性干皮病的基底细胞癌：一例报告及免疫组织化学研究

Furudate Sadanori, Fujimura Taku, Tojo Gen-Ichi, Haga Takahiro, Aiba Setsuya

Department of Dermatology, Yamato Takada Municipal Hospital, Nara.

Case Rep Dermatol. 2013 Mar 9;5(1):64-8. doi: 10.1159/000350182. Print 2013 Jan.

We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages, together with Foxp3(+) regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was also detected in the CD163(+) M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP.

我们描述了一名患有源于色素沉着干皮病（XP）的基底细胞癌的26岁日本患者。免疫组织化学染色显示CD163（+）M2巨噬细胞以及Foxp3（+）调节性T细胞密集浸润。有趣的是，在CD163（+）M2巨噬细胞浸润区域也检测到了MMP9，它被报道为免疫抑制性巨噬细胞的功能标志物之一。我们的病例提示了XP患者肿瘤发生的免疫背景。