在人类基因组中搜索重组基因基序。
A comprehensive search for recombinogenic motifs in the human genome.
机构信息
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
出版信息
PLoS One. 2013 Apr 23;8(4):e62920. doi: 10.1371/journal.pone.0062920. Print 2013.
The patterns of male and female recombination vary greatly on a macro scale. A unique motif in each gender, triggering a double strand break at its location, much in the way Chi sites operate in E. coli, could logically explain this difference. As such, we have undertaken a comprehensive search of all small motifs in an attempt to identify one or more that match to the available data. In the end, we conclude that no such motifs appear to exist in the human genome.
在宏观尺度上，男性和女性的重组模式差异很大。在每个性别中都有一个独特的基序，在其位置触发双链断裂，这种方式与大肠杆菌中的 Chi 位点非常相似，可以合理地解释这种差异。因此，我们进行了全面搜索所有的小基序，试图确定一个或多个与现有数据匹配的基序。最后，我们得出结论，人类基因组中似乎不存在这样的基序。
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