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环境木烟、交通污染与成人哮喘患病率和严重程度。

Ambient wood smoke, traffic pollution and adult asthma prevalence and severity.

机构信息

Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, University of Melbourne, Melbourne, Victoria, Australia.

出版信息

Respirology. 2013 Oct;18(7):1101-7. doi: 10.1111/resp.12108.

Abstract

BACKGROUND AND OBJECTIVE

The impact of ambient wood smoke and traffic-related air pollution on adult asthma has not been well studied. This paper aims to investigate associations between exposure to ambient wood smoke, traffic-related air pollution and current asthma/asthma severity in middle age, and whether any associations are modified by atopic status.

METHODS

Using data from the Tasmanian Longitudinal Health Study, associations between ambient wood smoke and two indices of traffic-related air pollution (frequency of heavy vehicles near the home and frequency of intense traffic noise) and current asthma/asthma severity were investigated. Unconditional logistic regression to examine current asthma and ordinal logistic regression to examine asthma severity was used.

RESULTS

For asthmatics, both exposure to ambient wood smoke (odds ratio 1.11; 95% confidence interval 1.02-1.20) and being frequently exposed to heavy vehicles (odds ratio 1.80; 95% confidence interval 1.09-2.96) were associated with increased asthma severity. Neither association varied by atopic status.

CONCLUSIONS

In middle-aged adults, ambient wood smoke and traffic pollution were associated with increased asthma severity. These findings suggest that avoiding or limiting exposure to traffic pollution and wood smoke may help to reduce asthma. Future studies to replicate this finding are recommended and should examine specific biological mechanisms for this effect.

摘要

背景与目的

环境木烟和交通相关空气污染对成人哮喘的影响尚未得到充分研究。本文旨在研究环境木烟、交通相关空气污染与中年时期当前哮喘/哮喘严重程度之间的关联,以及任何关联是否受特应性状态的影响。

方法

利用塔斯马尼亚纵向健康研究的数据,研究环境木烟与交通相关空气污染的两个指标(家中重型车辆的频率和强烈交通噪声的频率)与当前哮喘/哮喘严重程度之间的关系。采用无条件逻辑回归来检验当前哮喘,采用有序逻辑回归来检验哮喘严重程度。

结果

对于哮喘患者,暴露于环境木烟(比值比 1.11;95%置信区间 1.02-1.20)和经常接触重型车辆(比值比 1.80;95%置信区间 1.09-2.96)与哮喘严重程度增加相关。这两种关联均不受特应性状态的影响。

结论

在中年成年人中,环境木烟和交通污染与哮喘严重程度增加相关。这些发现表明,避免或限制接触交通污染和木烟可能有助于减少哮喘。建议进行未来的研究来复制这一发现,并应研究这种效应的具体生物学机制。

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