Harada K, Fujita N, Sakurai K, Kin S, Nakanishi K, Murakami T, Kozuka T
Department of Radiology, Osaka University Medical School.
Nihon Igaku Hoshasen Gakkai Zasshi. 1990 Feb 25;50(2):198-200.
A new pulse sequence for in vivo diffusion measurements by magnetic resonance imaging is introduced. The proposed sequence employed gradient sensitization in three orthogonal directions to accentuate the effects of diffusion. The amplitudes and durations of the diffusion encoding gradients were carefully selected to achieve optimal signal-to-noise ratio in diffusion imaging. The pulse sequence was implemented on a superconducting whole body imager operating at 1.5 T. The self-diffusion coefficient of water in a bottle was measured to be 2.17 +/- 0.089 X 10(-9) m2/sec at 23 degrees C consistent with other previous measurements. A preclinical study with a human volunteer was also performed and results were presented.
介绍了一种用于磁共振成像体内扩散测量的新脉冲序列。所提出的序列在三个正交方向上采用梯度敏感化以增强扩散效应。仔细选择扩散编码梯度的幅度和持续时间，以在扩散成像中实现最佳信噪比。该脉冲序列在一台运行于1.5T的超导全身成像仪上实现。在23℃下，测量瓶中水的自扩散系数为2.17±0.089×10⁻⁹m²/秒，这与之前的其他测量结果一致。还对一名人类志愿者进行了临床前研究并展示了结果。
