Thomsen C, Henriksen O, Ring P
Department of Magnetic Resonance, Hvidovre Hospital, University of Copenhagen, Denmark.
Acta Radiol. 1987 May-Jun;28(3):353-61.
A new pulse sequence for in vivo diffusion measurements by magnetic resonance imaging (MRI) is introduced. The pulse sequence was tested on phantoms to evaluate the accuracy, reproducibility and inplane variations. The sensitivity of the sequence was tested by measuring the self diffusion coefficient of water with different temperatures. This phantom study showed that the water self diffusion could be measured accurately and that the inplane deviation was less than +/- 10 per cent. Seven healthy volunteers were studied with a 10 mm thick slice through the lateral ventricles, clear differences between grey and white matter as well as regional differences within the white matter were seen. In two patients with infarction, alternations in water self diffusion were seen in the region of the infarct. Likewise, pronounced changes in brain water self diffusion were observed in a patient with benign intracranial hypertension. The results indicate that brain water self diffusion can be measured in vivo with reasonable accuracy. The clinical examples suggest that diffusion measurements may be clinically useful adding further information about in vivo MR tissue characterization.
介绍了一种用于磁共振成像（MRI）体内扩散测量的新脉冲序列。该脉冲序列在体模上进行了测试，以评估其准确性、可重复性和面内变化。通过测量不同温度下水的自扩散系数来测试该序列的灵敏度。该体模研究表明，可以准确测量水的自扩散，且面内偏差小于±10%。对7名健康志愿者进行了研究，通过10毫米厚的层面穿过侧脑室，观察到灰质和白质之间以及白质内的区域差异明显。在两名梗死患者中，梗死区域观察到水自扩散的改变。同样，在一名良性颅内高压患者中观察到脑水自扩散的明显变化。结果表明，可以在体内以合理的准确性测量脑水自扩散。临床实例表明，扩散测量可能在临床上有用，可为体内磁共振组织特征提供更多信息。
