Fundação Oswaldo Cruz - Fiocruz, Centro de Desenvolvimento Tecnológico em Saúde, Rio de Janeiro, Brazil.
Curr Opin Microbiol. 2013 Aug;16(4):414-20. doi: 10.1016/j.mib.2013.04.002. Epub 2013 Apr 27.
Fungal cells are efficient in releasing to the extracellular space molecules that lack typical secretion signals, including cytoplasmic components. Studies developed during the last five years indicate that extracellular vesicle formation is involved in the traffic of these intracellular components to the extracellular space. The cellular origin of these vesicles, however, is still unknown. Here we review the potential mechanisms involved in formation of fungal extracellular vesicles and consequent release of fungal molecules to the outer cellular space. We also propose that these compartments can originate from cytoplasmic subtractions whose formation is dependent on plasma membrane reshaping.
真菌细胞能够有效地将缺乏典型分泌信号的分子（包括细胞质成分）释放到细胞外空间。过去五年的研究表明，细胞外囊泡的形成参与了这些细胞内成分向细胞外空间的运输。然而，这些囊泡的细胞起源仍然未知。本文综述了真菌细胞外囊泡形成和真菌分子向细胞外空间释放的潜在机制，并提出这些隔室可能来源于细胞质的凹陷，其形成依赖于质膜的重塑。
