College of Medicine, Department of Internal Medicine, King Khalid University, Abha, Saudi Arabia.
Seizure. 2013 Sep;22(7):542-7. doi: 10.1016/j.seizure.2013.04.002. Epub 2013 Apr 28.
Epilepsy can develop at any age for reasons that remain poorly understood. The aim of this study was to determine the impact of a family history of epilepsy (FHE) on the incidence and recurrence of seizures.
This retrospective study was conducted in Aseer central hospital, Abha, Saudi Arabia between January and June 2012. The medical records of 420 patients were analyzed to test the impact of FHE on the risk factors, etiology and diagnosis of epilepsy determined by magnetic resonance imaging (MRI) and electroencephalography (EEG).
420 patients were studied. Idiopathic epilepsy was seen in 140 patients (33%), symptomatic in 152 (36%), and cryptogenic in 128 patients (30%). FHE was seen in 113 patients (27%), which was associated with younger at the disease onset (15 years vs 20 years, p<0.05). Idiopathic epilepsy was seen more in patients with FHE (43% vs 30%, p value <0.05), and generalized seizures (primary or secondary) were also seen more in patients with FHE (51% vs 36%, p value <0.05). Abnormal EEG was also seen more in patients with FHE (79% vs 66%, p<0.05). Multivariate regression analysis showed that temporal epileptic discharges were the best predictor for the presence of FHE (p<0.05, OR=3.1, 95% CI 1.7-5.8), more than idiopathic epilepsy or younger age at epilepsy onset.
FHE has a significant impact on epilepsy, its classifications, and the EEG findings, and may underlie the presence of a genetic etiology, which could be related to a high incidence of consanguinity seen in our population. Temporal epileptic discharges were the best predictor for FHE, which may suggest the presence of familial TLE.
癫痫可能因病因不明而在任何年龄发生。本研究旨在确定家族性癫痫病史（FHE）对癫痫发作的发生率和复发率的影响。
本回顾性研究于 2012 年 1 月至 6 月在沙特阿拉伯阿西尔省阿巴哈的中心医院进行。分析了 420 例患者的病历，以测试 FHE 对磁共振成像（MRI）和脑电图（EEG）确定的癫痫危险因素、病因和诊断的影响。
研究了 420 例患者。特发性癫痫 140 例（33%），症状性癫痫 152 例（36%），隐源性癫痫 128 例（30%）。FHE 见于 113 例（27%）患者，发病年龄较早（15 岁 vs 20 岁，p<0.05）。FHE 患者中更常见特发性癫痫（43% vs 30%，p 值<0.05），且 FHE 患者更常见全身性发作（原发性或继发性）（51% vs 36%，p 值<0.05）。FHE 患者的异常脑电图也更为常见（79% vs 66%，p<0.05）。多变量回归分析显示，颞叶癫痫放电是 FHE 存在的最佳预测因子（p<0.05，OR=3.1，95%CI 1.7-5.8），优于特发性癫痫或发病年龄较早。
FHE 对癫痫及其分类和 EEG 发现有显著影响，可能是遗传病因的基础，这可能与我们人群中高发的近亲结婚有关。颞叶癫痫放电是 FHE 的最佳预测因子，这可能提示存在家族性颞叶癫痫。
