Department of Psychiatry, Division of Schizophrenia and Related Disorders, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Drive, MC 7797, San Antonio, TX 78229, United States.
Schizophr Res. 2013 Jul;147(2-3):387-92. doi: 10.1016/j.schres.2013.04.003. Epub 2013 Apr 26.
Social cognitive impairment is related to poor social functioning in schizophrenia. This impairment includes both deficits in emotion perception and theory of mind (ToM), and cognitive biases including attributional bias and jumping to conclusions. Oxytocin (OXT) is a hormone that has been implicated in human social behavior, and that has also been associated with regulation of inflammation. In a cross-sectional study involving 60 patients with schizophrenia and 20 healthy controls, we examined associations between OXT and social cognitive capacity and bias. Secondary analyses examined associations between OXT and inflammation. We found significant correlations between OXT and social cognitive bias in the control group and in patients with delusions, but not in patients without delusions. Social cognitive capacity only correlated significantly with OXT in patients with delusions. A correlation between OXT and inflammation was observed only in patients without delusions. Findings suggest that OXT may be implicated in social cognition both in controls and in patients with delusions, but that this association may be blunted in patients without delusions. Inflammation appears to be related to OXT rather independently of social cognition. Future longitudinal and intervention studies with OXT are needed to clarify causality in the identified associations.
社会认知障碍与精神分裂症患者的社交功能不良有关。这种障碍包括情绪感知和心理理论（ToM）的缺陷，以及归因偏差和仓促结论等认知偏差。催产素（OXT）是一种与人类社会行为有关的激素，也与炎症的调节有关。在一项涉及 60 名精神分裂症患者和 20 名健康对照者的横断面研究中，我们研究了 OXT 与社会认知能力和偏差之间的关系。二次分析研究了 OXT 与炎症之间的关系。我们发现，在对照组和妄想患者中，OXT 与社会认知偏差之间存在显著相关性，但在没有妄想的患者中没有相关性。社会认知能力仅与妄想患者的 OXT 显著相关。只有在没有妄想的患者中才观察到 OXT 与炎症之间的相关性。研究结果表明，OXT 可能与对照组和妄想患者的社会认知都有关，但在没有妄想的患者中，这种相关性可能减弱。炎症似乎与 OXT 有关，而与社会认知无关。需要进行未来的纵向和干预研究，以阐明所确定关联中的因果关系。
