金黄色葡萄球菌的群体遗传学与毒力进化
Population genetics and the evolution of virulence in Staphylococcus aureus.
作者信息
Chua Kyra Y L, Howden Benjamin P, Jiang Jhih-Hang, Stinear Timothy, Peleg Anton Y
机构信息
Department of Microbiology and Immunology, University of Melbourne, Victoria 3052, Australia; Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria 3084, Australia; Microbiology Department, Austin Health, Heidelberg, Victoria 3084, Australia.
Department of Microbiology and Immunology, University of Melbourne, Victoria 3052, Australia; Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia; Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria 3084, Australia; Microbiology Department, Austin Health, Heidelberg, Victoria 3084, Australia.
出版信息
Infect Genet Evol. 2014 Jan;21:554-62. doi: 10.1016/j.meegid.2013.04.026. Epub 2013 Apr 27.
Staphylococcus aureus is one of the most important human pathogens, causing life-threatening infection in the community and hospital setting. The population genetics of S. aureus and the evolution of virulence is the focus of this review. We describe the various techniques in determining S. aureus population structure and discuss the insights gained from whole genome sequencing of various S. aureus strains. The emergence of community-acquired, methicillin-resistant S. aureus provides a framework for the discussion on evolution of virulence, and the role of horizontal gene transfer in the development of virulence and antibiotic resistance is explored. The knowledge generated from population genetics has the potential to inform strategies to assist in the prevention or treatment of this highly successful human pathogen.
金黄色葡萄球菌是最重要的人类病原体之一，在社区和医院环境中可引发危及生命的感染。金黄色葡萄球菌的群体遗传学及毒力进化是本综述的重点。我们描述了确定金黄色葡萄球菌群体结构的各种技术，并讨论了从各种金黄色葡萄球菌菌株的全基因组测序中获得的见解。社区获得性耐甲氧西林金黄色葡萄球菌的出现为讨论毒力进化提供了框架，并探讨了水平基因转移在毒力和抗生素耐药性发展中的作用。群体遗传学产生的知识有可能为协助预防或治疗这种非常成功的人类病原体的策略提供信息。
Zotero 插件