Laboratório de Virologia, Departamento de Genética Evolução e Bioagentes, Instituto de Biologia/Universidade Estadual de Campinas-UNICAMP, Cx. Postal 6109, CEP 13083-970 , Campinas/SP/Brazil.
Viruses. 2013 Apr 29;5(5):1219-30. doi: 10.3390/v5051219.
The Hepatitis C virus causes chronic infections in humans, which can develop to liver cirrhosis and hepatocellular carcinoma. The Bovine viral diarrhea virus is used as a surrogate model for antiviral assays for the HCV. From marine invertebrates and microorganisms isolated from them, extracts were prepared for assessment of their possible antiviral activity. Of the 128 tested, 2 were considered active and 1 was considered promising. The best result was obtained from the extracts produced from the Bacillus sp. isolated from the sponge Petromica citrina. The extracts 555 (500 µg/mL, SI>18) and 584 (150 µg/mL, SI 27) showed a percentage of protection of 98% against BVDV, and the extract 616, 90% of protection. All of them showed activity during the viral adsorption. Thus, various substances are active on these studied organisms and may lead to the development of drugs which ensure an alternative therapy for the treatment of hepatitis C.
丙型肝炎病毒可引起人类慢性感染，继而发展为肝硬化和肝细胞癌。牛病毒性腹泻病毒常被用作丙型肝炎病毒抗病毒检测的替代模型。从海洋无脊椎动物及其分离得到的微生物中提取了各种物质，评估它们的潜在抗病毒活性。在测试的 128 种物质中，有 2 种被认为具有活性，1 种被认为具有开发前景。从分离自海绵 Petromica citrina 的芽孢杆菌属中提取的物质的效果最好。提取物 555（500µg/mL，SI>18）和 584（150µg/mL，SI 27）对 BVDV 的保护率达到 98%，提取物 616 的保护率为 90%。所有这些提取物在病毒吸附过程中都表现出了活性。因此，各种物质对这些研究对象都具有活性，这可能会促使开发出确保丙型肝炎治疗替代疗法的药物。
