金黄色葡萄球菌群体感应的多价修饰。
Multivalent alteration of quorum sensing in Staphylococcus aureus.
机构信息
Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
Chem Commun (Camb). 2013 Jun 7;49(45):5177-9. doi: 10.1039/c3cc41645c.
PMID:23628938
Abstract
Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4' units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.
摘要
金黄色葡萄球菌的毒力与局部细胞密度呈强正相关。在这里，我们提出了一种使用多价肽-聚合物缀合物来调节这种群体行为的有效方法。我们的结果表明，通过将多个 AIP-4' 单位连接到高分子支架上，可以强烈影响金黄色葡萄球菌的 agr QS 反应，同时表现出明显的多价效应。
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