使用负载自诱导物的纳米颗粒调节霍乱弧菌群体感应控制的通讯
Modulating Vibrio cholerae quorum-sensing-controlled communication using autoinducer-loaded nanoparticles.
作者信息
Lu Hoang D, Spiegel Alina C, Hurley Amanda, Perez Lark J, Maisel Katharina, Ensign Laura M, Hanes Justin, Bassler Bonnie L, Semmelhack Martin F, Prud'homme Robert K
机构信息
∥Department of Chemistry and Biochemistry, Rowan University, Glassboro, New Jersey 08028, United States.
○Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States.
出版信息
Nano Lett. 2015 Apr 8;15(4):2235-41. doi: 10.1021/acs.nanolett.5b00151. Epub 2015 Mar 3.
Abstract
The rise of bacterial antibiotic resistance has created a demand for alternatives to traditional antibiotics. Attractive possibilities include pro- and anti-quorum sensing therapies that function by modulating bacterial chemical communication circuits. We report the use of Flash NanoPrecipitation to deliver the Vibrio cholerae quorum-sensing signal CAI-1 ((S)-3-hydroxytridecan-4-one) in a water dispersible form as nanoparticles. The particles activate V. cholerae quorum-sensing responses 5 orders of magnitude higher than does the identically administered free CAI-1 and are diffusive across in vivo delivery barriers such as intestinal mucus. This work highlights the promise of combining quorum-sensing strategies with drug delivery approaches for the development of next-generation medicines.
摘要
细菌对抗生素耐药性的增加引发了对传统抗生素替代品的需求。有吸引力的可能性包括通过调节细菌化学通讯回路起作用的群体感应促进和群体感应抑制疗法。我们报告了使用快速纳米沉淀法将霍乱弧菌群体感应信号CAI-1（(S)-3-羟基十三烷-4-酮）以纳米颗粒的形式制成水分散体。这些颗粒激活霍乱弧菌群体感应反应的能力比同等剂量的游离CAI-1高5个数量级，并且能够扩散穿过体内递送屏障，如肠道黏液。这项工作突出了将群体感应策略与药物递送方法相结合以开发下一代药物的前景。
相似文献
1
Modulating Vibrio cholerae quorum-sensing-controlled communication using autoinducer-loaded nanoparticles.使用负载自诱导物的纳米颗粒调节霍乱弧菌群体感应控制的通讯
Nano Lett. 2015 Apr 8;15(4):2235-41. doi: 10.1021/acs.nanolett.5b00151. Epub 2015 Mar 3.
2
Synthesis and Evaluation of Indole-Based Autoinducers on Quorum Sensing in .基于吲哚的群体感应自动诱导物的合成与评价 。
ACS Infect Dis. 2020 Apr 10;6(4):572-576. doi: 10.1021/acsinfecdis.9b00409. Epub 2020 Mar 23.
3
The intragenus and interspecies quorum-sensing autoinducers exert distinct control over Vibrio cholerae biofilm formation and dispersal.种内和种间群体感应自诱导物对霍乱弧菌生物膜形成和分散有不同的控制作用。
PLoS Biol. 2019 Nov 11;17(11):e3000429. doi: 10.1371/journal.pbio.3000429. eCollection 2019 Nov.
4
The major Vibrio cholerae autoinducer and its role in virulence factor production.霍乱弧菌主要自诱导物及其在毒力因子产生中的作用。
Nature. 2007 Dec 6;450(7171):883-6. doi: 10.1038/nature06284. Epub 2007 Nov 14.
5
The Vibrio cholerae Quorum-Sensing Protein VqmA Integrates Cell Density, Environmental, and Host-Derived Cues into the Control of Virulence.霍乱弧菌群体感应蛋白 VqmA 将细胞密度、环境和宿主来源的信号整合到毒力调控中。
mBio. 2020 Jul 28;11(4):e01572-20. doi: 10.1128/mBio.01572-20.
6
Role of methylthioadenosine/S-adenosylhomocysteine nucleosidase in Vibrio cholerae cellular communication and biofilm development.甲硫腺苷/S-腺苷高半胱氨酸核苷酶在霍乱弧菌细胞通讯和生物膜形成中的作用
Biochem Biophys Res Commun. 2015 May 22;461(1):65-9. doi: 10.1016/j.bbrc.2015.03.170. Epub 2015 Apr 4.
7
Mechanism of Vibrio cholerae autoinducer-1 biosynthesis.霍乱弧菌自诱导物-1 的生物合成机制。
ACS Chem Biol. 2011 Apr 15;6(4):356-65. doi: 10.1021/cb1003652. Epub 2011 Jan 13.
8
Three autoinducer molecules act in concert to control virulence gene expression in Vibrio cholerae.三种自动诱导分子协同作用控制霍乱弧菌毒力基因的表达。
Nucleic Acids Res. 2019 Apr 8;47(6):3171-3183. doi: 10.1093/nar/gky1320.
9
The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA.霍乱弧菌群体感应自诱导物CAI-1：生物合成酶CqsA的分析
Nat Chem Biol. 2009 Dec;5(12):891-5. doi: 10.1038/nchembio.237. Epub 2009 Oct 18.
10
Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule through the AWCON neuron.秀丽隐杆线虫通过AWCON神经元识别一种细菌群体感应信号分子。
J Biol Chem. 2014 Sep 19;289(38):26566-26573. doi: 10.1074/jbc.M114.573832. Epub 2014 Aug 4.
引用本文的文献
1
Nanomaterials Regulate Bacterial Quorum Sensing: Applications, Mechanisms, and Optimization Strategies.纳米材料调控细菌群体感应：应用、机制与优化策略。
Adv Sci (Weinh). 2024 Apr;11(15):e2306070. doi: 10.1002/advs.202306070. Epub 2024 Feb 13.
2
Attenuation of quorum sensing system and virulence in by phytomolecules.植物分子对群体感应系统及毒力的减弱作用 （原文中“by phytomolecules”前缺少具体主语，译文按大概意思补充完整了表述）
Front Microbiol. 2023 Mar 30;14:1133569. doi: 10.3389/fmicb.2023.1133569. eCollection 2023.
3
Nanomaterials and Coatings for Managing Antibiotic-Resistant Biofilms.用于管理抗生素耐药生物膜的纳米材料与涂层
Antibiotics (Basel). 2023 Feb 2;12(2):310. doi: 10.3390/antibiotics12020310.
4
Innovative microbial disease biocontrol strategies mediated by quorum quenching and their multifaceted applications: A review.群体淬灭介导的创新型微生物病害生物防治策略及其多方面应用：综述
Front Plant Sci. 2023 Jan 12;13:1063393. doi: 10.3389/fpls.2022.1063393. eCollection 2022.
5
[Not Available].[无可用内容]
Angew Chem Int Ed Engl. 2022 Mar 25;61(24):e202201798. doi: 10.1002/anie.202201798.
6
Flash Technology-Based Self-Assembly in Nanoformulation: From Fabrication to Biomedical Applications.基于闪蒸技术的纳米制剂自组装：从制备到生物医学应用
Mater Today (Kidlington). 2021 Jan-Feb;42:99-116. doi: 10.1016/j.mattod.2020.08.019. Epub 2020 Nov 2.
7
Inhibition of Biofilm Formation with Surface Modified Polymeric Nanoparticles.表面改性聚合物纳米颗粒对生物膜形成的抑制作用
Pathogens. 2019 Apr 24;8(2):55. doi: 10.3390/pathogens8020055.
8
Nanoparticles for Signaling in Biodiagnosis and Treatment of Infectious Diseases.用于传染病生物诊断和治疗的信号传导纳米粒子。
Int J Mol Sci. 2018 May 31;19(6):1627. doi: 10.3390/ijms19061627.
9
Surface-attached molecules control Staphylococcus aureus quorum sensing and biofilm development.表面附着的分子控制金黄色葡萄球菌群体感应和生物膜的形成。
Nat Microbiol. 2017 May 22;2:17080. doi: 10.1038/nmicrobiol.2017.80.
10
Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control.抑制金黄色葡萄球菌群体感应的非织造聚合物纳米纤维涂层：迈向感染控制的新型非杀菌方法
ACS Infect Dis. 2017 Apr 14;3(4):271-280. doi: 10.1021/acsinfecdis.6b00173. Epub 2017 Feb 20.
本文引用的文献
1
Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse.表面化学对纳米颗粒与胃肠道黏液相互作用以及小鼠口服和直肠给药后在胃肠道中分布的影响。
J Control Release. 2015 Jan 10;197:48-57. doi: 10.1016/j.jconrel.2014.10.026. Epub 2014 Nov 4.
2
Mucus models to evaluate nanomedicines for diffusion.用于评估纳米药物扩散的黏液模型。
Drug Discov Today. 2014 Aug;19(8):1097-108. doi: 10.1016/j.drudis.2014.01.011. Epub 2014 Jan 31.
3
Highly Potent, Chemically Stable Quorum Sensing Agonists for .用于……的高效、化学稳定的群体感应激动剂
Chem Sci. 2014 Jan 1;5(1):151-155. doi: 10.1039/C3SC52572D.
4
Overcoming the unexpected functional inversion of a PqsR antagonist in Pseudomonas aeruginosa: an in vivo potent antivirulence agent targeting pqs quorum sensing.克服铜绿假单胞菌 PqsR 拮抗剂的意外功能反转：一种针对群体感应 pqs 的体内有效抗毒剂。
Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1109-12. doi: 10.1002/anie.201307547. Epub 2013 Dec 11.
5
Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes.聚合物诱导细菌聚类，从而引发群体感应控制表型的表达。
Nat Chem. 2013 Dec;5(12):1058-65. doi: 10.1038/nchem.1793. Epub 2013 Nov 10.
6
Antibiotic resistance: the last resort.抗生素耐药性：最后的手段。
Nature. 2013 Jul 25;499(7459):394-6. doi: 10.1038/499394a.
7
Multivalent alteration of quorum sensing in Staphylococcus aureus.金黄色葡萄球菌群体感应的多价修饰。
Chem Commun (Camb). 2013 Jun 7;49(45):5177-9. doi: 10.1039/c3cc41645c.
8
Exploiting quorum sensing to confuse bacterial pathogens.利用群体感应来扰乱细菌病原体。
Microbiol Mol Biol Rev. 2013 Mar;77(1):73-111. doi: 10.1128/MMBR.00046-12.
9
Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers.通过聚合物纳米载体的多价表面修饰优化细胞受体特异性靶向。
J Control Release. 2013 May 28;168(1):41-9. doi: 10.1016/j.jconrel.2013.02.004. Epub 2013 Feb 16.
10
Encapsulated fusion protein confers "sense and respond" activity to chitosan-alginate capsules to manipulate bacterial quorum sensing.包封融合蛋白为壳聚糖-海藻酸钠胶囊赋予“感知和响应”活性，以操纵细菌群体感应。
Biotechnol Bioeng. 2013 Feb;110(2):552-62. doi: 10.1002/bit.24711. Epub 2012 Sep 18.
Zotero 插件