16α-羟基-(-)-贝壳杉酸：一种来自牛心番荔枝的具有选择性细胞毒性的二萜类化合物。
16 alpha-hydroxy-(-)-kauranoic acid: a selectively cytotoxic diterpene from Annona bullata.
作者信息
Hui Y H, Chang C J, Smith D L, McLaughlin J L
机构信息
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
出版信息
Pharm Res. 1990 Apr;7(4):376-8. doi: 10.1023/a:1015819422479.
Using brine shrimp lethality to direct fractionation, extracts of the bark of Annona bullata Rich. (Annonaceae) have yielded 16 alpha-hydroxy-(-)-kauranoic acid as a bioactive plant constituent. This previously known diterpene showed significant (ED50 8.25 x 10(-2) micrograms/ml) and selective cytotoxicity against A-549 (lung) cells in our panel of human tumor cells.
利用卤虫致死率进行直接分级分离，牛心番荔枝（番荔枝科）树皮提取物得到了16α-羟基-（-）-贝壳杉酸作为一种生物活性植物成分。这种先前已知的二萜在我们的人类肿瘤细胞组中对A-549（肺）细胞显示出显著的（半数有效剂量8.25×10⁻²微克/毫升）和选择性细胞毒性。
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