植物抗癌剂，XLVI。胡克钩枝藤的细胞毒性卡斯巴烷型成分。
Plant anticancer agents, XLVI. Cytotoxic casbane-type constituents of Agrostistachys hookeri.
作者信息
Choi Y H, Pezzuto J M, Kinghorn A D, Farnsworth N R
机构信息
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
出版信息
J Nat Prod. 1988 Jan-Feb;51(1):110-6. doi: 10.1021/np50055a016.
In addition to the previously characterized agrostistachin, three additional cytotoxic macrocyclic casbane-type diterpenes were isolated from a CHCl3 extract of Agrostistachys hookeri, by bioactivity-guided fractionation using the P-388 lymphocytic leukemia cell culture system. These novel compounds, 14-dehydroagrostistachin, 17-hydroxyagrostistachin, and agroskerin, identified by spectral data comparison to agrostistachin and demonstrated ED50 values of 2.8, 0.8, and 1.4 micrograms/ml, respectively, with cultured P-388 cells.
除了之前已鉴定的钩穗草素外，通过使用P - 388淋巴细胞白血病细胞培养系统进行生物活性导向分级分离，从钩穗草的氯仿提取物中又分离出三种具有细胞毒性的大环乌苏烷型二萜。通过与钩穗草素的光谱数据比较鉴定出这些新化合物，分别为14 - 脱氢钩穗草素、17 - 羟基钩穗草素和钩穗草灵，它们对培养的P - 388细胞的半数有效剂量（ED50）值分别为2.8、0.8和1.4微克/毫升。
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