Rochester, Minn. From the Division of Plastic and Reconstructive Surgery and the Department of Orthopedics, Mayo Clinic.
Plast Reconstr Surg. 2013 May;131(5):771e-778e. doi: 10.1097/PRS.0b013e3182865cf3.
Merkel cell carcinoma is a rare, aggressive cutaneous malignancy with high rates of recurrence, metastases, and mortality. Its nonspecific clinical presentation often delays the diagnosis, and its treatment is still controversial because of the infrequent nature of the tumor. The authors provide an overview of the current literature on epidemiology, cause, pathogenesis, staging, management, and outcomes of this disease. Effective diagnostic and treatment modalities such as wide local excision of the primary tumor, importance of sentinel node biopsy for staging, evidence for the use of adjuvant radiation therapy, and emphasis on a multidisciplinary treatment approach of Merkel cell carcinoma as it pertains to surgical practice are reviewed.
默克尔细胞癌是一种罕见的侵袭性皮肤恶性肿瘤，具有较高的复发率、转移率和死亡率。其非特异性的临床表现常导致诊断延迟，且由于肿瘤的罕见性，其治疗仍存在争议。作者就该疾病的流行病学、病因、发病机制、分期、治疗和预后的现有文献进行了综述。本文回顾了有效的诊断和治疗方法，如原发肿瘤的广泛局部切除术、前哨淋巴结活检的重要性、辅助放疗的应用证据，以及强调多学科治疗方法在手术实践中的应用，以治疗默克尔细胞癌。
