Koay Su-Yin, Lee Richard M H, Hugkulstone Charles, Rodrigues Ian Aureliano Stephen
Ophthalmology Department, Queen Mary's Hospital, Kent, UK.
BMJ Case Rep. 2014 Aug 14;2014:bcr2013202979. doi: 10.1136/bcr-2013-202979.
A 97-year-old woman presented with a 5-month history of a rapidly growing, painless, left upper eyelid lesion. Examination revealed a large vascularised, ulcerated nodule on the left upper lid, causing significant ptosis. Wide local excision of the lesion was performed and the wound was left to heal by secondary intention. Histology and immunohistochemistry of the lesion confirmed a diagnosis of Merkel cell carcinoma, a rare primary malignancy of the eyelid which has significant morbidity and mortality. Although uncommon, this diagnosis should always be considered in any patient with a rapidly growing lid lump. In view of the patient's age, known dementia and family wishes, the patient was managed conservatively, with no further investigations performed. She was due to be followed up in clinic on a regular basis, but has since died from other causes.
一名97岁女性因左上眼睑出现一个迅速生长、无痛性病变5个月前来就诊。检查发现左上眼睑有一个大的血管化、溃疡结节,导致明显的上睑下垂。对病变进行了广泛局部切除,伤口让其二期愈合。病变的组织学和免疫组化检查确诊为默克尔细胞癌,这是一种罕见的眼睑原发性恶性肿瘤,具有较高的发病率和死亡率。尽管不常见,但对于任何有迅速生长的眼睑肿块的患者都应始终考虑到这种诊断。鉴于患者的年龄、已知的痴呆症以及家属的意愿,对患者进行了保守治疗,未进行进一步检查。她本应定期到门诊随访,但后来因其他原因去世。