一名老年女性的母细胞性浆细胞样树突状细胞肿瘤

Blastic plasmacytoid dendritic cell neoplasm in an elderly woman.

作者信息

Foong H B B, Chong M, Taylor E M, Carlson J A, Petrella T

机构信息

Universiti Kuala Lumpur Royal College of Medicine Perak, Department of Medicine, No. 3, Jalan Greentown, Ipoh, Perak 30450 Malaysia.

出版信息

Med J Malaysia. 2013 Apr;68(2):161-3.

PMID:23629565

Abstract

Blastic plasmacytoid dendritic cell neoplasm (a.k.a. NK cell lymphoma, CD4+CD56+ haematodermic neoplasm) is a rare aggressive tumour that arises from plasmacytoid dendritic cell precursors. We report the first case from Malaysia of a 79-year-old Chinese woman who presented with purpuric plaques and nodules produced by pleomorphic CD4+, CD56+, CD68+, CD123+ and CD303+, but CD2APmononuclear cell infiltrates. Leukemic dissemination occurred and she succumbed to disease without treatment 4 weeks after diagnosis and 9 months after onset of cutaneous disease.

摘要

母细胞性浆细胞样树突状细胞肿瘤（又称NK细胞淋巴瘤、CD4⁺CD56⁺血液肿瘤）是一种罕见的侵袭性肿瘤，起源于浆细胞样树突状细胞前体。我们报告马来西亚首例79岁华裔女性病例，该患者出现由多形性CD4⁺、CD56⁺、CD68⁺、CD123⁺和CD303⁺，但CD2AP单核细胞浸润产生的紫癜性斑块和结节。发生了白血病播散，她在诊断后4周和皮肤病发作后9个月未经治疗死于该疾病。