Eone Reference Laboratory, Seoul, South Korea.
J Epidemiol. 2013;23(4):270-4. doi: 10.2188/jea.je20120188. Epub 2013 Apr 27.
We evaluated the recent prevalence of serologic markers of hepatitis A virus (HAV) in South Korea.
The study data were the results of 60 126 anti-HAV (total) tests and 30 786 anti-HAV IgM tests that were performed during April 2009 through March 2010 by the Eone Reference Laboratory at the request of 1935 institutions throughout Korea.
The overall positivity rate was 51.06% on the anti-HAV (total) test and 11.20% on the anti-HAV IgM test. As compared with the other age groups the rate of anti-HAV (total) positivity was significantly lower (P < 0.001), and the rate of anti-HAV IgM positivity was significantly higher (P < 0.001), among Koreans aged 11 to 40 years. The seroprevalence of anti-HAV IgM significantly differed according to region but not by referral date.
This was the largest nationwide study in South Korea by 1 laboratory, and it provides useful recent baseline data on hepatitis A in Asia. The findings suggest that active immunization of younger Koreans should be made a priority.
我们评估了韩国近期甲型肝炎病毒 (HAV) 血清学标志物的流行情况。
本研究的数据来自于 2009 年 4 月至 2010 年 3 月期间，1935 家韩国医疗机构通过 Eone 参考实验室提出的要求，共进行了 60126 项抗-HAV（总）检测和 30786 项抗-HAV IgM 检测。
抗-HAV（总）检测的总阳性率为 51.06%，抗-HAV IgM 检测的阳性率为 11.20%。与其他年龄组相比，11 至 40 岁人群的抗-HAV（总）阳性率明显较低（P<0.001），抗-HAV IgM 阳性率明显较高（P<0.001）。抗-HAV IgM 的血清流行率因地区而异，但与转诊日期无关。
这是由 1 家实验室在韩国进行的最大规模的全国性研究，为亚洲的甲型肝炎提供了有用的近期基线数据。研究结果表明，应优先考虑为年轻的韩国人进行主动免疫接种。
