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韩国军队中慢性乙型肝炎感染者甲型肝炎疫苗接种率和血清流行病学研究。

Vaccination rate and seroepidemiology of hepatitis a in chronic-hepatitis-B-infected individuals in the korean army.

机构信息

Department of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

出版信息

Gut Liver. 2010 Jun;4(2):207-11. doi: 10.5009/gnl.2010.4.2.207. Epub 2010 Jun 16.

Abstract

BACKGROUND/AIMS: Vaccination against hepatitis A virus (HAV) is recommended for patients with chronic hepatitis B (CHB), since they are potentially at an increased risk of HAV-related morbidity and mortality. However, little is known about the adherence to these recommendations in the community. This study evaluated the current vaccination status and immunity against HAV among Korean military soldiers with CHB.

METHODS

We performed a prospective study of Korean military soldiers from August 2008 to January 2009. We enrolled 96 soldiers with CHB on a consecutive basis. We assessed their vaccination history and the presence of anti-HAV immunoglobulin G (IgG).

RESULTS

The HAV vaccination rate of the soldiers enrolled in our study was 2% (2 of the 96 soldiers). The seroprevalence rates of anti-HAV IgG among military soldiers without a vaccination history were 0%, 50%, and 100% for those aged 19-29 years (n=71), 30-39 years (n=8), and 40 years or older (n=15), respectively (p<0.001).

CONCLUSIONS

The HAV vaccination rate is very low among military soldiers. Public health efforts aimed at raising awareness about HAV vaccination in patients with CHB should be strongly encouraged.

摘要

背景/目的:由于慢性乙型肝炎(CHB)患者存在发生甲型肝炎病毒(HAV)相关发病率和死亡率增加的潜在风险,因此建议对其进行 HAV 疫苗接种。然而,对于社区中这些建议的遵循情况知之甚少。本研究评估了韩国军队中患有 CHB 的士兵的当前疫苗接种状况和对 HAV 的免疫力。

方法

我们于 2008 年 8 月至 2009 年 1 月对韩国军队士兵进行了一项前瞻性研究。我们连续纳入了 96 名 CHB 士兵。我们评估了他们的疫苗接种史和抗-HAV 免疫球蛋白 G(IgG)的存在情况。

结果

我们研究中纳入的士兵中 HAV 疫苗接种率为 2%(96 名士兵中有 2 名)。无疫苗接种史的军事人员抗-HAV IgG 的血清阳性率分别为 0%、50%和 100%,年龄分别为 19-29 岁(n=71)、30-39 岁(n=8)和 40 岁或以上(n=15)(p<0.001)。

结论

军队士兵的 HAV 疫苗接种率非常低。应大力鼓励开展公共卫生工作,提高 CHB 患者对 HAV 疫苗接种的认识。

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