Kaufmann C, Bochmann F, Baenninger P, Thiel M A
Dept. of Ophthalmology, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Klin Monbl Augenheilkd. 2013 Apr;230(4):333-6. doi: 10.1055/s-0032-1328382. Epub 2013 Apr 29.
Combined excimer laser correction and corneal cross-linking is a promising concept in treating keratoconus patients. Central corneal regularization represents advanced topography-guided custom ablation for ectatic corneas, aiming at correcting irregular astigmatism and at increasing the optical regularity of the corneal surface.
In a prospective single centre study, 10 keratoconus patients underwent combined treatment with corneal cross-linking and central corneal regularization by an iRES-Laser. Uncorrected visual acuity at 1 and 3 months postoperatively represented the primary endpoint.
Mean preoperative uncorrected decimal visual acuity was 0.15 (± 0.28 standard deviation). Mean postoperative visual acuity was 0.28 (± 0.47) at one month and 0.24 (± 0.25) at three months, respectively.
Combined corneal cross-linking and central corneal regularization treatment has the potential to achieve a clinically significant improvement of uncorrected visual acuity.
准分子激光矫正联合角膜交联术是治疗圆锥角膜患者的一个有前景的概念。中央角膜规则化代表了针对扩张性角膜的先进的地形引导定制消融，旨在矫正不规则散光并提高角膜表面的光学规则性。
在一项前瞻性单中心研究中，10例圆锥角膜患者接受了角膜交联术联合iRES激光中央角膜规则化治疗。术后1个月和3个月的未矫正视力作为主要终点指标。
术前平均未矫正小数视力为0.15（标准差±0.28）。术后1个月平均视力为0.28（±0.47），3个月时为0.24（±0.25）。
角膜交联术联合中央角膜规则化治疗有可能在临床上显著提高未矫正视力。
