与人类糖尿病神经病变相关的运动单位丧失和无力。
Motor unit loss and weakness in association with diabetic neuropathy in humans.
机构信息
School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, London, Ontario N6G 1H1, Canada.
出版信息
Muscle Nerve. 2013 Aug;48(2):298-300. doi: 10.1002/mus.23792. Epub 2013 Apr 30.
INTRODUCTION
Diabetes mellitus can be associated with peripheral neuropathy which may affect numbers of functioning motor units (MUs) of limb muscles. Direct quantitative assessment of MU numbers and muscle strength have not been performed in humans. We compared the estimated number of MUs of individuals with diabetic polyneuropathy (DPN) versus controls.
METHODS
Patients with signs/symptoms of DPN were studied using decomposition-enhanced quantitative electromyography of the tibialis anterior (TA). Motor unit number estimates were derived from this analysis.
RESULTS
Dorsiflexion strength was ∼60% less in DPN than controls (P < 0.05). Additionally, the estimated number of functioning TA MUs was ∼60% fewer in patients with DM (∼46) versus controls (∼111) (P < 0.05).
CONCLUSIONS
These data directly measure MU loss associated with DPN in a proximal muscle in humans. It remains to be determined whether quantifying MU loss has clinical utility in monitoring the progression or management of DPN.
简介
糖尿病可伴有周围神经病变，这可能会影响四肢肌肉的运动单位（MU）的功能数量。尚未在人体中进行 MU 数量和肌肉力量的直接定量评估。我们比较了糖尿病性多发性神经病（DPN）患者与对照组个体的估计 MU 数量。
方法
使用胫骨前肌（TA）的分解增强定量肌电图对有 DPN 体征/症状的患者进行研究。从该分析中得出运动单位数量的估计值。
结果
DPN 患者的背屈强度比对照组低约 60%（P<0.05）。此外，与对照组（111）相比，DM 患者的 TA 运动单位数量估计值减少了约 60%（46）（P<0.05）。
结论
这些数据直接测量了与人类近端肌肉 DPN 相关的 MU 丧失。目前尚不确定定量测量 MU 丧失是否在监测 DPN 的进展或管理方面具有临床实用性。
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