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鉴定木樨草素对胰岛素样生长因子-1 配体-受体相互作用的抑制机制。

Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction.

机构信息

Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA.

出版信息

Chembiochem. 2013 May 27;14(8):929-33. doi: 10.1002/cbic.201300082. Epub 2013 Apr 29.

DOI:10.1002/cbic.201300082
PMID:23630137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3940256/
Abstract

Using single-molecule force measurement and fluorescence imaging, we have demonstrated that luteolin has an inhibitory effect on IGF-1 ligand-receptor binding, the initial step in IGF-1 signaling. This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy.

摘要

通过单分子力测量和荧光成像，我们已经证明了木犀草素对 IGF-1 配体-受体结合具有抑制作用，而 IGF-1 信号转导的第一步就是配体-受体结合。这种抑制机制已通过流式细胞术和分子对接得到证实，它可能在癌症治疗中发挥作用。

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Platinum squares with high selectivity and affinity for human telomeric G-quadruplexes.具有高选择性和亲和力的人端粒 G-四链体的铂正方形。
Chem Commun (Camb). 2012 Aug 7;48(61):7607-9. doi: 10.1039/c2cc32942e. Epub 2012 Jun 25.
3
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Endocrinol Metab Clin North Am. 2012 Jun;41(2):335-50, vi. doi: 10.1016/j.ecl.2012.04.014.
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A steric blocker of translation elongation inhibits IGF-1R expression and cell transformation.一个翻译延伸的空间位阻阻断物抑制 IGF-1R 的表达和细胞转化。
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Nat Rev Cancer. 2008 Dec;8(12):915-28. doi: 10.1038/nrc2536.
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