Department of Biology, University of Washington, Seattle, WA 98195, USA.
J Exp Bot. 2013 Jun;64(9):2557-63. doi: 10.1093/jxb/ert100. Epub 2013 Apr 29.
How does auxin provoke such a diverse array of responses? This long-standing question is further complicated by a remarkably short nuclear auxin signalling pathway. To crack the auxin code, several potential sources of specificity need to be evaluated. These include: specificity of interactions among the core auxin response components, specificity resulting from higher order complex dynamics, and specificity in interactions with global factors controlling protein turnover and transcriptional repression. Here, we review recent progress towards characterizing and quantifying these interactions and highlight key gaps that remain.
生长素如何引发如此多样化的反应？这个长期存在的问题因核生长素信号通路非常短而变得更加复杂。为了解开生长素密码，需要评估几个潜在的特异性来源。这些包括：核心生长素反应成分之间相互作用的特异性、更高阶复杂动力学产生的特异性，以及与控制蛋白质周转和转录抑制的全局因素相互作用的特异性。在这里，我们回顾了最近在描述和量化这些相互作用方面取得的进展，并强调了仍然存在的关键差距。
