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灌洗疗法与非手术疗法治疗颞下颌关节疼痛:随机对照试验的系统评价

Lavage therapy versus nonsurgical therapy for the treatment of arthralgia of the temporomandibular joint: a systematic review of randomized controlled trials.

作者信息

Vos Lukas M, Huddleston Slater James J R, Stegenga Boudewijn

机构信息

Department of Oral and Maxilliofacial Surgery, University Medical Center Groningen, The Netherlands.

出版信息

J Orofac Pain. 2013 Spring;27(2):171-9. doi: 10.11607/jop.1007.

Abstract

AIMS

To carry out a systematic review of randomized controlled trials (RCTs) to investigate in patients with arthralgia of the temporomandibular joint (TMJ) the effectiveness of TMJ lavage compared to nonsurgical treatment with regard to pain intensity and mandibular range of motion.

METHODS

The electronic databases Cochrane Controlled Trials Register (1960-2012), PubMed÷Medline (1966-2012), and Embase (1966-2012) were systematically searched for relevant RCTs. References of relevant articles were searched for additional studies, as well as citing reports. Two authors independently performed data extraction by using predefined quality indicators. Relevant outcome data included reduction in pain, as assessed by a visual analog scale (VAS) or a pain score, and maximal mouth opening (MMO) before and 6 months after treatment. Included trials were combined using fixed and random effects meta-analysis.

RESULTS

Three RCTs (222 patients) were included for meta-analysis. The statistically significant overall standardized mean difference (SMD) (P < .001) with regard to pain intensity was -1.07 (95% CI = -1.38, - 0.76) in favor of TMJ lavage. The MMO did not change significantly (P > .05, SMD = .05 [95% CI = -0.33, 0.23]).

CONCLUSIONS

The results suggest that lavage of the TMJ may be slightly more effective than nonsurgical treatment for pain reduction. However, this difference is not likely to be clinically relevant.

摘要

目的

对随机对照试验(RCT)进行系统评价,以研究颞下颌关节(TMJ)疼痛患者中,与非手术治疗相比,TMJ灌洗在疼痛强度和下颌运动范围方面的有效性。

方法

系统检索电子数据库Cochrane对照试验注册库(1960 - 2012年)、PubMed÷Medline(1966 - 2012年)和Embase(1966 - 2012年),查找相关RCT。检索相关文章的参考文献以获取更多研究以及引用报告。两名作者使用预定义的质量指标独立进行数据提取。相关结局数据包括通过视觉模拟量表(VAS)或疼痛评分评估的疼痛减轻情况,以及治疗前和治疗后6个月的最大张口度(MMO)。纳入的试验使用固定效应和随机效应荟萃分析进行合并。

结果

三项RCT(222例患者)纳入荟萃分析。在疼痛强度方面,具有统计学意义的总体标准化均数差(SMD)(P <.001)为-1.07(95%CI = -1.38,-0.76),支持TMJ灌洗。MMO没有显著变化(P>.05,SMD =.05 [95%CI = -0.33,0.23])。

结论

结果表明,TMJ灌洗在减轻疼痛方面可能比非手术治疗略有效。然而,这种差异可能在临床上不具有相关性。

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