TRIM 蛋白作为 RING 指结构域 E3 泛素连接酶。

TRIM proteins as RING finger E3 ubiquitin ligases.

机构信息

Division of Gene Regulation and Signal Transduction, Research Centerfor Genomic Medicine, Saitama Medical University, Saitama, Japan.

出版信息

Adv Exp Med Biol. 2012;770:27-37. doi: 10.1007/978-1-4614-5398-7_3.

DOI:10.1007/978-1-4614-5398-7_3

PMID:23630998

Abstract

The tripartite motif(TRIM) proteins harboring the RING finger, B-box and coiled-coil (RBCC) domain motifs form a large protein family. The members of this family are involved in various biological processes, including growth, differentiation, apoptosis and transcription and also in diseases and oncogenesis. Recent studies have revealed that TRIM proteins play key roles in innate antiviral immunity. An accumulating body of evidence has demonstrated that some TRIM proteins function as E3 ubiquitin ligases in specific ubiquitin-mediated protein degradation pathways; however, the precise mechanisms underlying this function have not been fully elucidated. In this chapter, we focus on the TRIM family of proteins specially with regard to E3 ligase.

摘要

三基序蛋白（TRIM）含有环指、B -box 和卷曲螺旋（RBCC）结构域基序，形成一个庞大的蛋白质家族。该家族的成员参与各种生物学过程，包括生长、分化、凋亡和转录，也参与疾病和肿瘤发生。最近的研究表明，TRIM 蛋白在先天抗病毒免疫中发挥关键作用。越来越多的证据表明，一些 TRIM 蛋白作为 E3 泛素连接酶在特定的泛素介导的蛋白降解途径中发挥作用；然而，这一功能的确切机制尚未完全阐明。在本章中，我们特别关注 E3 连接酶的 TRIM 蛋白家族。