Hepatic Surgery Center, and Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Clinical Medical Research Center of Hepatic Surgery at Hubei Province, Wuhan, Hubei, China.
J Biomed Sci. 2022 Sep 13;29(1):69. doi: 10.1186/s12929-022-00854-7.
The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function as E3 ligases to facilitate specific proteasomal degradation of target proteins. In addition, E3 ligase independent functions of TRIM protein were also reported. In hepatocellular carcinoma, expressions of TRIM proteins are both regulated by genetic and epigenetic mechanisms. TRIM proteins regulate multiple biological activities and signaling cascades. And TRIM proteins influence hallmarks of HCC. This review systematically demonstrates the versatile roles of TRIM proteins in HCC and helps us better understand the molecular mechanism of the development and progression of HCC.
三基序蛋白（TRIM）家族是一组高度保守的 E3 连接酶家族，在人类中已知有 77 个成员，其中大多数由一个 RING 指结构域、一个或两个 B 盒结构域和一个卷曲螺旋结构域组成。一般来说，TRIM 蛋白作为 E3 连接酶，促进靶蛋白的特定蛋白酶体降解。此外，也有报道称 TRIM 蛋白具有 E3 连接酶非依赖性功能。在肝细胞癌中，TRIM 蛋白的表达受遗传和表观遗传机制的调节。TRIM 蛋白调节多种生物学活性和信号级联反应，并影响 HCC 的标志性特征。本综述系统地展示了 TRIM 蛋白在 HCC 中的多种作用，有助于我们更好地理解 HCC 发生和发展的分子机制。
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