Shimizu Wataru
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center.
Nihon Rinsho. 2013 Jan;71(1):161-6.
Atrial fibrillation (AF) is one of the most common arrhythmias, especially in elderly subjects. During the last decade, the contribution of genetic factors in pathogenesis of AF has been focused. Three categories of genetic patterns are considered to relate to AF: (1) familial AF as a monogenic disease, (2) familial AF presenting in the setting of another inherited cardiac diseases (hypertrophic cardiomyopathy, dilated cardiomyopathy, familial amyloidosis) or another inherited arrhythmic syndromes (congenital long QT syndrome, short QT syndrome, Brugada syndrome), and (3) non-familial AF associated with genetic backgrounds that may predispose to AF, such as a polymorphism in the ACE gene. More recently, the genome-wide association study (GWAS) has identified several genomic regions associated with AF. In this review article, genetic backgrounds underlying familial and non-familial AF will be discussed.
心房颤动（AF）是最常见的心律失常之一，在老年人群中尤为常见。在过去十年中，遗传因素在房颤发病机制中的作用受到了关注。三类遗传模式被认为与房颤有关：（1）作为单基因疾病的家族性房颤；（2）在另一种遗传性心脏病（肥厚型心肌病、扩张型心肌病、家族性淀粉样变性）或另一种遗传性心律失常综合征（先天性长QT综合征、短QT综合征、Brugada综合征）背景下出现的家族性房颤；（3）与可能易患房颤的遗传背景相关的非家族性房颤，如ACE基因多态性。最近，全基因组关联研究（GWAS）已经确定了几个与房颤相关的基因组区域。在这篇综述文章中，将讨论家族性和非家族性房颤的遗传背景。
