辅酶Q10单次静脉输注保护大鼠心肌免受后续缺血/再灌注损伤

[Coenzyme Q10 single intravenous infusion protects rat myocardium against subsequent ischemia/reperfusion].

作者信息

Ivanov A V, Gorodetskaia E A, Kalenikova E I, Medvedev O S

出版信息

Eksp Klin Farmakol. 2013;76(2):6-8.

Abstract

Cardioprotective effects of coenzyme Q10 (CoQ10) injected intravenously 30 min before coronary artery occlusion were assessed on the model of myocardial ischemia/reperfusion in Wistar rats. Rats treated with CoQ10 after 30 min of ischemia and 120 min of reperfusion exhibited smaller (by 35%, p < 0.01) size of irreversibly damaged myocardium, shorter duration and decreased number of arrhythmias during reperfusion, and increased content of myocardial CoQ10 (by 210%, p < 0.01) as compared to saline-treated rats. Increased CoQ10 levels in myocardium were accompanied by smaller size of damaged myocardium (r = -0.77, p = 0.0002). Thus, there is evidence of the cardioprotective effect of CoQ10 injected intravenously before myocardial ischemia/reperfusion.

摘要

在Wistar大鼠心肌缺血/再灌注模型上评估了在冠状动脉闭塞前30分钟静脉注射辅酶Q10（CoQ10）的心脏保护作用。在缺血30分钟和再灌注120分钟后用CoQ10治疗的大鼠与用生理盐水治疗的大鼠相比，不可逆损伤心肌的面积更小（小35%，p<0.01），再灌注期间心律失常的持续时间更短且数量减少，心肌CoQ10含量增加（增加210%，p<0.01）。心肌中CoQ10水平的升高伴随着受损心肌面积的减小（r=-0.77，p=0.0002）。因此，有证据表明在心肌缺血/再灌注前静脉注射CoQ10具有心脏保护作用。