Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Ophthalmology. 2013 Sep;120(9):1756-60. doi: 10.1016/j.ophtha.2013.01.062. Epub 2013 Apr 28.
Rapid assessments of vision commonly rely on visual acuity testing alone. Although well suited for uncovering optical defects, visual acuity tests may fail to detect dysfunction of the neural substrate. There is a need for a rapid companion test sensitive to neural damage.
Evaluation of diagnostic tests.
Forty-seven patients with optic nerve or visual pathway lesions of low to moderate severities and 30 normal subjects.
A new computer-based quick test of neurovisual integrity was developed using segmented digits defined by rarebits, that is, receptive field-size bright dots briefly presented on a dark background.
The test variable was the number of rarebits per segment; digit size was fixed. The test task was to call out verbally all digits that were seen during an 8-second presentation sequence. Test outcomes were contrasted with the results of an optotype acuity test and automated perimetry.
All subjects easily grasped the test task. The normal subjects read, on average, 5.6 (± 0.5 standard deviation) of the 6 digits contained in the test sequence, whereas the patients averaged 3.3 ± 1.8 digits. The numbers of digits read correlated modestly with the acuity and perimetry results. Analysis of receiver operating characteristic curves indicated that the multiple rarebit test provided the best discrimination.
The multiple rarebit test seemed to be highly capable of detecting neurovisual dysfunction. Its simplicity and uniquely short duration indicate a useful role in screening settings. The test is available free on the Internet.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
视力的快速评估通常仅依赖于视力测试。虽然视力测试非常适合发现光学缺陷，但它可能无法检测到神经基质的功能障碍。因此，需要一种快速的、对神经损伤敏感的伴随测试。
诊断测试的评估。
47 名视神经或视觉通路病变程度较低至中度的患者和 30 名正常受试者。
使用由 rarebits 定义的分段数字开发了一种新的基于计算机的神经视觉完整性快速测试，即，短暂地在暗背景上呈现大小为感受野的亮点的稀有位。
测试变量是每个分段的 rarebits 数量；数字大小固定。测试任务是在 8 秒的呈现序列中口头说出所有可见的数字。测试结果与视力表视力测试和自动视野计的结果进行对比。
所有受试者都轻松掌握了测试任务。正常受试者平均能读出测试序列中包含的 6 个数字中的 5.6 个（±0.5 个标准差），而患者平均只能读出 3.3 ±1.8 个。读出的数字与视力和视野计结果有一定的相关性。受试者工作特征曲线的分析表明，多位 rarebit 测试提供了最佳的区分能力。
多位 rarebit 测试似乎非常能够检测神经视觉功能障碍。它的简单性和独特的短持续时间表明它在筛查环境中有很大的作用。该测试可在互联网上免费获得。
参考文献后可能会发现专有或商业披露。
