利用时域测量的空间频域滤波进行混浊介质中的荧光寿命检测。
Fluorescence lifetime detection in turbid media using spatial frequency domain filtering of time domain measurements.
机构信息
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
出版信息
Opt Lett. 2013 May 1;38(9):1440-2. doi: 10.1364/OL.38.001440.
Abstract
It is demonstrated that high spatial frequency filtering of time domain fluorescence signals can allow efficient detection of intrinsic fluorescence lifetimes from turbid media and the rejection of diffuse excitation leakage. The basis of this approach is the separation of diffuse fluorescence signals into diffuse and fluorescent components with distinct spatiotemporal behavior.
摘要
研究表明，对时域荧光信号进行高空间频率滤波可以有效地从混浊介质中检测固有荧光寿命，并消除漫反射激发泄漏。这种方法的基础是将漫反射荧光信号分离为具有不同时空行为的漫反射和荧光分量。
相似文献
1
Fluorescence lifetime detection in turbid media using spatial frequency domain filtering of time domain measurements.利用时域测量的空间频域滤波进行混浊介质中的荧光寿命检测。
Opt Lett. 2013 May 1;38(9):1440-2. doi: 10.1364/OL.38.001440.
2
Locating and classifying fluorescent tags behind turbid layers using time-resolved inversion.利用时间分辨反演技术定位和分类混浊层后的荧光标记物。
Nat Commun. 2015 Apr 13;6:6796. doi: 10.1038/ncomms7796.
3
Drug quantification in turbid media by fluorescence imaging combined with light-absorption correction using white Monte Carlo simulations.利用荧光成像结合使用白光蒙特卡罗模拟进行吸光度校正的浊度介质中的药物定量。
J Biomed Opt. 2011 Jun;16(6):066002. doi: 10.1117/1.3585675.
4
Functional optical detection based on pH dependent fluorescence lifetime.基于pH依赖性荧光寿命的功能性光学检测。
Lasers Surg Med. 2004;35(5):342-8. doi: 10.1002/lsm.20101.
5
Quantitative fluorescence lifetime spectroscopy in turbid media: comparison of theoretical, experimental and computational methods.混浊介质中的定量荧光寿命光谱学：理论、实验与计算方法的比较
Phys Med Biol. 2002 Sep 21;47(18):3387-405. doi: 10.1088/0031-9155/47/18/308.
6
Simple time-domain optical method for estimating the depth and concentration of a fluorescent inclusion in a turbid medium.用于估计浑浊介质中荧光内含物深度和浓度的简单时域光学方法。
Opt Lett. 2004 Oct 1;29(19):2258-60. doi: 10.1364/ol.29.002258.
7
Localization and quantification of fluorescent inclusions embedded in a turbid medium.嵌入浑浊介质中的荧光内含物的定位与定量分析。
Phys Med Biol. 2005 May 21;50(10):2313-27. doi: 10.1088/0031-9155/50/10/009. Epub 2005 May 5.
8
A thermo-sensitive fluorescent agent based method for excitation light leakage rejection for fluorescence molecular tomography.基于热敏荧光剂的荧光分子层析成像激发光漏泄消除方法。
Phys Med Biol. 2019 Jan 22;64(3):035007. doi: 10.1088/1361-6560/aaf96d.
9
Optical phantoms with variable properties and geometries for diffuse and fluorescence optical spectroscopy.具有可变性质和几何形状的光学模型，用于漫反射和荧光光谱学。
J Biomed Opt. 2012 Oct;17(10):108001. doi: 10.1117/1.JBO.17.10.108001.
10
Spatial intensity distribution model of fluorescence emission considering the spatial attenuation effect of excitation light.考虑激发光空间衰减效应的荧光发射空间强度分布模型。
Opt Express. 2021 Mar 1;29(5):6468-6480. doi: 10.1364/OE.416452.
引用本文的文献
1
Propagation of time-resolved fluorescence in a diffuse medium: complex analytical derivation.时间分辨荧光在漫射介质中的传播：复杂的解析推导
J Opt Soc Am A Opt Image Sci Vis. 2020 May 1;37(5):859-864. doi: 10.1364/JOSAA.388762.
2
Spatial frequency domain imaging in 2019: principles, applications, and perspectives.空间频域成像 2019：原理、应用及展望。
J Biomed Opt. 2019 Jun;24(7):1-18. doi: 10.1117/1.JBO.24.7.071613.
3
Generalized mesh-based Monte Carlo for wide-field illumination and detection via mesh retessellation.基于广义网格的蒙特卡罗方法，用于通过网格重新细分实现宽场照明和检测。
Biomed Opt Express. 2015 Dec 18;7(1):171-84. doi: 10.1364/BOE.7.000171. eCollection 2016 Jan 1.
本文引用的文献
1
Lifetime-based tomographic multiplexing.基于寿命的断层成像多路复用。
J Biomed Opt. 2010 Jul-Aug;15(4):046011. doi: 10.1117/1.3469797.
2
Time-resolved diffuse optical tomography with patterned-light illumination and detection.基于图案化光照明和探测的时分辨散光学层析成像。
Opt Lett. 2010 Jul 1;35(13):2121-3. doi: 10.1364/OL.35.002121.
3
Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties.用于组织光学特性无创测量的时间分辨反射率和透射率。
Appl Opt. 1989 Jun 15;28(12):2331-6. doi: 10.1364/AO.28.002331.
4
Fluorescence lifetime measurements and biological imaging.荧光寿命测量与生物成像。
Chem Rev. 2010 May 12;110(5):2641-84. doi: 10.1021/cr900343z.
5
Time resolved fluorescence tomography of turbid media based on lifetime contrast.基于寿命对比度的混浊介质时间分辨荧光层析成像。
Opt Express. 2006 Dec 11;14(25):12255-70. doi: 10.1364/oe.14.012255.
6
Quantitation and mapping of tissue optical properties using modulated imaging.使用调制成像技术对组织光学特性进行定量和映射。
J Biomed Opt. 2009 Mar-Apr;14(2):024012. doi: 10.1117/1.3088140.
7
Temporal propagation of spatial information in turbid media.空间信息在浑浊介质中的时间传播。
Opt Lett. 2008 Dec 1;33(23):2836-8. doi: 10.1364/ol.33.002836.
8
Fluorescence-lifetime-based tomography for turbid media.用于浑浊介质的基于荧光寿命的层析成像技术。
Opt Lett. 2005 Dec 15;30(24):3347-9. doi: 10.1364/ol.30.003347.
Zotero 插件