Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Opt Lett. 2013 May 1;38(9):1440-2. doi: 10.1364/OL.38.001440.
It is demonstrated that high spatial frequency filtering of time domain fluorescence signals can allow efficient detection of intrinsic fluorescence lifetimes from turbid media and the rejection of diffuse excitation leakage. The basis of this approach is the separation of diffuse fluorescence signals into diffuse and fluorescent components with distinct spatiotemporal behavior.
研究表明，对时域荧光信号进行高空间频率滤波可以有效地从混浊介质中检测固有荧光寿命，并消除漫反射激发泄漏。这种方法的基础是将漫反射荧光信号分离为具有不同时空行为的漫反射和荧光分量。
