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精英运动表现的基因组学:我们所知甚少和必要的进展。

Genomics of elite sporting performance: what little we know and necessary advances.

机构信息

College of Medicine, Veterinary and Life Sciences, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Lanarkshire, UK.

出版信息

Br J Sports Med. 2013 Jun;47(9):550-5. doi: 10.1136/bjsports-2013-092400. Epub 2013 Apr 30.

DOI:10.1136/bjsports-2013-092400
PMID:23632745
Abstract

Numerous reports of genetic associations with performance-related phenotypes have been published over the past three decades but there has been limited progress in discovering and characterising the genetic contribution to elite/world-class performance, mainly owing to few coordinated research efforts involving major funding initiatives/consortia and the use primarily of the candidate gene analysis approach. It is timely that exercise genomics research has moved into a new era utilising well-phenotyped, large cohorts and genome-wide technologies--approaches that have begun to elucidate the genetic basis of other complex traits/diseases. This review summarises the most recent and significant findings from sports genetics and explores future trends and possibilities.

摘要

在过去的三十年中,已经发表了许多关于与表现相关的表型的遗传关联的报告,但在发现和描述精英/世界级表现的遗传贡献方面进展有限,主要是由于涉及主要资助计划/联盟的协调研究工作较少,并且主要使用候选基因分析方法。运动基因组学研究利用表型良好的大型队列和全基因组技术进入了一个新时代,这一趋势已经开始阐明其他复杂特征/疾病的遗传基础,这是适时的。本文综述了运动遗传学的最新和重要发现,并探讨了未来的趋势和可能性。

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