Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.
Kidney Int. 2013 May;83(5):777-9. doi: 10.1038/ki.2012.469.
Parathyroid hormone-related protein (PTHrP) is a pleiotropic factor with multiple physiological functions in morphogenesis, cell proliferation, differentiation, apoptosis, and calcium homeostasis. In the kidney, PTHrP is known to be expressed abundantly and to be upregulated in various experimental nephropathies, showing growth-modulatory and proinflammatory properties. Ardura et al. demonstrate a possible link between PTHrP-induced Runx2 expression and an antiapoptotic effect in tubular epithelial cells.
甲状旁腺激素相关蛋白 (PTHrP) 是一种多效因子，在形态发生、细胞增殖、分化、凋亡和钙稳态中具有多种生理功能。在肾脏中，已知 PTHrP 大量表达，并在各种实验性肾病中上调，表现出生长调节和促炎特性。Ardura 等人证明了 PTHrP 诱导的 Runx2 表达与管状上皮细胞抗凋亡作用之间的可能联系。
