Kang Seok Seon, Ko Eun Young, Han Boo-Kyung, Shin Jung Hee, Hahn Soo Yeon, Ko Eun Sook
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Magn Reson Imaging. 2014 Mar;39(3):526-34. doi: 10.1002/jmri.24185. Epub 2013 Apr 30.
To evaluate the menstrual cycle and breast composition influence on background parenchymal enhancement of breast magnetic resonance imaging (MRI) and to investigate the optimal time for breast MR examinations.
We evaluated the dynamic contrast-enhanced breast MR images of 238 women who had completed a questionnaire survey about menstrual status. On MRI, the degree of enhancement (DE) of normal parenchyma was measured in the images 2 minutes and 6 minutes after contrast injection. A comparison between premenopausal and postmenopausal women and a separate comparison between dense breasts and fatty breasts were analyzed according to the premenopausal women's menstrual cycle.
Premenopausal women showed significantly higher DE than the postmenopausal women (P<0.001). In premenopausal women, overall DE of fatty breasts and dense breasts was not different. However, fatty breasts showed the highest DE in the 4th week and lowest DE in the 2nd week, while dense breasts showed the highest DE in the 3rd week and the lowest DE in the 4th week of menstrual cycle.
The influence of menstrual cycle on the enhancement of breast parenchyma is different according to the breast composition. The optimal time for breast MRI could be different for dense and fatty breasts.
评估月经周期和乳腺组成对乳腺磁共振成像（MRI）背景实质强化的影响，并探讨乳腺磁共振检查的最佳时间。
我们评估了238名完成月经状况问卷调查的女性的动态对比增强乳腺MR图像。在MRI上，于注射对比剂后2分钟和6分钟的图像中测量正常实质的强化程度（DE）。根据绝经前女性的月经周期，对绝经前和绝经后女性进行比较，并对致密型乳腺和脂肪型乳腺分别进行比较。
绝经前女性的DE显著高于绝经后女性（P<0.001）。在绝经前女性中，脂肪型乳腺和致密型乳腺的总体DE无差异。然而，脂肪型乳腺在月经周期的第4周DE最高，第2周最低，而致密型乳腺在月经周期的第3周DE最高，第4周最低。
月经周期对乳腺实质强化的影响因乳腺组成不同而有所差异。致密型乳腺和脂肪型乳腺的乳腺MRI最佳时间可能不同。
