基于人群的口咽癌发病率趋势评估，重点关注社会经济地位、性别和种族/民族。
Population-based evaluation of incidence trends in oropharyngeal cancer focusing on socioeconomic status, sex, and race/ethnicity.
机构信息
Stanford Division of Medical Oncology, Stanford Cancer Institute, Stanford University Medical Center, Stanford, California.
出版信息
Head Neck. 2014 Jan;36(1):34-42. doi: 10.1002/hed.23253. Epub 2013 Apr 30.
BACKGROUND
The influences of socioeconomic status (SES) on the incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) are unclear.
METHODS
Data from the California Cancer Registry and U.S. Census were used to compare incidence rates and trends of OPSCC and other human papillomavirus-related and -unrelated cancer sites by neighborhood SES, race/ethnicity, and sex.
RESULTS
The incidence of OPSCC rose in both higher and lower SES neighborhoods. Absolute rates were greater in the latter. Only non-Hispanic white males with OPSCC demonstrated a significant increase in the incidence rate of squamous cell carcinoma of the head and neck (SCCHN). The incidence rate for this group increased from 4.5/100,000 person-years between 1988 and 1992 to 7.1 between 2003 and 2009. Regression analysis demonstrated an annual percentage change of 1% from 1988 to 1997 and 4% thereafter.
CONCLUSIONS
Increases in incidence rates are SES independent. Incidence rates are higher in lower-SES groups. The rise in OPSCC incidence is limited to non-Hispanic white males.
背景
社会经济地位（SES）对口咽鳞状细胞癌（OPSCC）发病率的影响尚不清楚。
方法
利用加利福尼亚癌症登记处和美国人口普查数据，按社区 SES、种族/族裔和性别比较 OPSCC 及其他人乳头瘤病毒相关和不相关癌症部位的发病率和趋势。
结果
高 SES 和低 SES 社区的 OPSCC 发病率均上升。后者的绝对发病率更高。只有 OPSCC 的非西班牙裔白人男性的头颈部鳞状细胞癌（SCCHN）发病率显著增加。该组的发病率从 1988 年至 1992 年的 4.5/100,000人年增加到 2003 年至 2009 年的 7.1。回归分析显示，1988 年至 1997 年每年百分比变化为 1%，此后每年百分比变化为 4%。
结论
发病率的增加与 SES 无关。发病率在 SES 较低的群体中更高。OPSCC 发病率的上升仅限于非西班牙裔白人男性。
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