Zhuo H T, Chen G
General Hospital of Nanjing Armed Forcer, Nanjing.
Yao Xue Xue Bao. 1990;25(1):1-5.
Cyclosporine was extracted from whole blood and analyzed by HPLC. The pharmacokinetics of oral cyclosporine were studied in patients with renal transplant. They were 5 women and 3 men between the ages of 29-49 years. Cyclosporine was used for 47 days to 11 months after renal transplantation. The mean dose was 8.26 +/- 1.41 mg/kg.d (5.88-10.0 mg/kg.d), once each 12 hours. Three hundreds whole blood samples were monitored. The peak concentration (Cmax) was 664.9 +/- 87.5 ng/ml; peak time was 3.27 +/- 1.07 h; slow elimination phase t1/2 beta was 13.53 (6.13-43.3) h.
从全血中提取环孢素并用高效液相色谱法进行分析。在肾移植患者中研究了口服环孢素的药代动力学。他们是5名女性和3名男性，年龄在29至49岁之间。肾移植后使用环孢素47天至11个月。平均剂量为8.26±1.41mg/kg.d（5.88 - 10.0mg/kg.d），每12小时给药一次。监测了300份全血样本。峰值浓度（Cmax）为664.9±87.5ng/ml；达峰时间为3.27±1.07小时；消除缓慢相t1/2β为13.53（6.13 - 43.3）小时。
