Ramon M, Morel D, Penouil F, Grellet J, Potaux L, Saux M C, Brachet-Liermain A
Therapie. 1989 Sep-Oct;44(5):371-4.
The circadian intraindividual variations of cyclosporin blood concentrations were studied in nine renal transplant patients at steady state. The cyclosporin was administrated orally twice a day (9 a.m. and 21 p.m.). Blood concentrations were analysed by H.P.L.C. AUC = area under the drug concentration versus time curve, Cmax = maximum blood concentration, Cmin = minimum blood concentration, Tmax = Time to maximum concentration. Statistical analysis (t, Wilcoxon) shows: AUC, Cmax and Tmax are not significantly modified, Cmin (21) less than Cmin (9) (p less than 0.02). This phenomenon seems to be rather a cyclosporin metabolism variation than an absorption alteration.
在9名处于稳态的肾移植患者中研究了环孢素血药浓度的昼夜个体内变化。环孢素每天口服两次（上午9点和晚上9点）。通过高效液相色谱法分析血药浓度。AUC = 药物浓度-时间曲线下面积，Cmax = 血药最大浓度，Cmin = 血药最小浓度，Tmax = 达到最大浓度的时间。统计分析（t检验、威尔科克森检验）显示：AUC、Cmax和Tmax无显著改变，Cmin（晚上9点）低于Cmin（上午9点）（p<0.02）。这种现象似乎是环孢素代谢的变化而非吸收改变。
