Sun K L, Li R S, Lei X H
Shanghai Institute of Pharmaceutical Industry.
Yao Xue Xue Bao. 1990;25(1):73-6.
Ten new shikimic acid derivatives, some of which are analogs of dioxolamycin were synthesized from methyl shikimate because the bioactivity of shikimic acid derivatives has received considerably less attention to date. Compounds 4-10, 12, 16 were subjected to antimicrobial test in vitro, and showed no activity (MIC greater than 25 micrograms/ml). Compounds 4-10, 12, 13, and 16 were subjected to cytostatic activity test against cultured L 1210 Leukemia cells in vitro. Compounds 4, 6, 13 and 16 showed cytostatic activity like dioxolamycin.
从莽草酸甲酯合成了10种新的莽草酸衍生物，其中一些是二氧霉素的类似物，因为迄今为止莽草酸衍生物的生物活性受到的关注要少得多。化合物4 - 10、12、16进行了体外抗菌测试，结果显示无活性（最小抑菌浓度大于25微克/毫升）。化合物4 - 10、12、13和16进行了体外对培养的L 1210白血病细胞的细胞生长抑制活性测试。化合物4、6、13和16显示出与二氧霉素类似的细胞生长抑制活性。
