Yamasato T, Nakayama S
Department of Physiology, Okayama University Medical School, Japan.
Acta Med Okayama. 1990 Apr;44(2):79-86. doi: 10.18926/AMO/30441.
The participation of the parasympathetic and sympathetic nerves in the canine gallbladder motility was examined. Efferent stimulation of the parasympathetic (vagus) and sympathetic (celiac) nerves caused contraction or inhibition of the neck, body and fundus of the gallbladder. The contractile response induced by vagus nerve stimulation was reduced by subthreshold efferent stimulation of the celiac nerve, while the inhibitory response was neither reduced nor enhanced by subthreshold efferent stimulation of the celiac nerve. The contractile and inhibitory response induced by celiac nerve stimulation was not reduced in the neck, body and fundus by subthreshold efferent stimulation of the vagus nerve. The contractile response to vagus nerve stimulation was reversed to a relaxant response by atropine administration, which was reduced or abolished by hexamethonium. It is suggested that the vagus nerve-induced contractile response in the canine gallbladder is modulated by sympathetic nerves presynaptically at the vagus nerve endings in the enteric ganglion, but the vagus nerve-induced relaxant response, which probably was induced by non-adrenergic non-cholinergic inhibitory neurons, is not modulated by the sympathetic nerves.
研究了副交感神经和交感神经对犬胆囊运动的参与情况。副交感神经（迷走神经）和交感神经（腹腔神经）的传出刺激可引起胆囊颈部、体部和底部的收缩或抑制。迷走神经刺激引起的收缩反应可被腹腔神经的阈下传出刺激所减弱，而腹腔神经的阈下传出刺激对抑制反应既无减弱也无增强作用。迷走神经的阈下传出刺激对腹腔神经刺激引起的收缩和抑制反应在胆囊颈部、体部和底部均无减弱作用。阿托品给药可使迷走神经刺激引起的收缩反应转变为松弛反应，而六甲铵可使其减弱或消除。提示犬胆囊中迷走神经诱导的收缩反应在肠神经节的迷走神经末梢处由交感神经进行突触前调节，但迷走神经诱导的松弛反应（可能由非肾上腺素能非胆碱能抑制性神经元诱导）不受交感神经调节。
