Wadhawan Amit, Gowda Triveni Mavinakote, Mehta Dhoom Singh
Department of Periodontology and Implantology, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India.
Contemp Clin Dent. 2012 Oct;3(4):406-11. doi: 10.4103/0976-237X.107427.
Successful reconstruction of periodontal tissues destroyed due to periodontitis has been an evasive goal for the periodontists. Several GTR materials and bone grafts have been tried with varied success rates.
The aim of the present study was to evaluate and compare the efficacy of non-resorbable (GoreTex(®)) and bioabsorbable (Resolut Adapt(®)) membranes in combination with bioactive glass (PerioGlas(®)) in the treatment of periodontal intrabony defects.
Ten chronic periodontitis patients having bilateral matched intrabony defects were treated with non-resorbable membrane (GoreTex(®)) and bioactive glass or the bioresorbable membrane (Resolut Adapt(®)) and bioactive glass in split mouth design. Clinical parameters like plaque index, gingival index, probing pocket depth, clinical attachment level, and gingival recession were recorded at baseline and 9 months post-operatively. Similarly, radiographic (linear CADIA) and intra-surgical (re-entry) measurements were evaluated at baseline and 9 months post-operatively).
Both the membrane groups showed clinically and statistically significant improvement in clinical parameters i.e., reduction in probing depth (4.6 ± 1.4 mm) vs. 3.7 ± 1.3 mm) and gain in clinical attachment level (4.6 + 1.6 vs. 3.2 ± 1.5 mm) for non-resorbable and bioresorbable membrane groups, respectively. Similar trend was observed when radiographical and intra-surgical (re-entry) measurements were evaluated and compared, pre- and post-operatively at 9 months. However, on comparison between the two groups, the difference was statistically not significant.
Both the barrier membranes i.e., non-resorbable (Gore-Tex(®)) and bioabsorbable (Resolut Adapt(®)) membranes in combination with bioactive glass (PerioGlas(®)) were equally effective in enhancing the periodontal regeneration.
成功重建因牙周炎而破坏的牙周组织一直是牙周病医生难以实现的目标。人们尝试了多种引导组织再生（GTR）材料和骨移植材料，成功率各不相同。
本研究的目的是评估和比较不可吸收（GoreTex®）和可生物吸收（Resolut Adapt®）膜联合生物活性玻璃（PerioGlas®）治疗牙周骨内缺损的疗效。
采用双盲设计，对10例患有双侧匹配骨内缺损的慢性牙周炎患者，一侧使用不可吸收膜（GoreTex®）和生物活性玻璃，另一侧使用可生物吸收膜（Resolut Adapt®）和生物活性玻璃进行治疗。在基线和术后9个月记录菌斑指数、牙龈指数、探诊袋深度、临床附着水平和牙龈退缩等临床参数。同样，在基线和术后9个月评估影像学（线性CADIA）和手术中（再次手术）测量结果。
两组膜在临床参数上均显示出临床和统计学上的显著改善，即不可吸收膜组和可生物吸收膜组的探诊深度分别降低（4.6±1.4mm对3.7±1.3mm）和临床附着水平增加（4.6+1.6对3.2±1.5mm）。在术后9个月进行术前和术后影像学及手术中（再次手术）测量评估和比较时，观察到类似趋势。然而，两组之间的差异在统计学上不显著。
不可吸收（Gore-Tex®）和可生物吸收（Resolut Adapt®）膜联合生物活性玻璃（PerioGlas®）这两种屏障膜在促进牙周再生方面同样有效。
