Swain D G, Nightingale P G, Gama R, Buckley B M
Department of Geriatric Medicine, Sandwell District General Hospital, West Bromwich.
Age Ageing. 1990 May;19(3):207-11. doi: 10.1093/ageing/19.3.207.
The pattern of enzyme changes in elderly fallers admitted to an acute geriatric unit was investigated. Creatine kinase (CK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) activities were measured daily for 3 days after admission in all patients in whom a fall preceded admission. Of 270 patients, 52 (19%) had fallen prior to admission, of whom five (10%) had an acute myocardial infarction (AMI). In fallers without an AMI in whom a history was available, CK and AST activities were significantly higher (p less than 0.05) in patients who had spent more than 1 hour on the floor than in those who had spent less than 1 hour. No other clinical factor affected enzyme activities. CK and AST activities were raised in 66% and 40%, respectively, of fallers without an AMI. Elevation of CK and AST activities in elderly fallers is likely to be a result of the fall itself rather than of an AMI.
对入住急性老年病科的老年跌倒患者的酶变化模式进行了研究。在所有入院前发生跌倒的患者中，入院后连续3天每天测量肌酸激酶（CK）、天冬氨酸转氨酶（AST）和乳酸脱氢酶（LDH）的活性。270例患者中，52例（19%）在入院前跌倒，其中5例（10%）发生急性心肌梗死（AMI）。在没有AMI且有病史的跌倒患者中，跌倒后在地面停留超过1小时的患者的CK和AST活性显著高于停留时间少于1小时的患者（p<0.05）。没有其他临床因素影响酶活性。在没有AMI的跌倒患者中，CK和AST活性升高的比例分别为66%和40%。老年跌倒患者CK和AST活性升高可能是跌倒本身所致，而非AMI所致。
