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BMJ. 2015 May 14;350:h2102. doi: 10.1136/bmj.h2102.

本文引用的文献

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Codeine and morphine pathway.可待因与吗啡途径。
Pharmacogenet Genomics. 2009 Jul;19(7):556-8. doi: 10.1097/FPC.0b013e32832e0eac.
2
Adverse neurodevelopmental outcome of infants exposed to opiate in-utero.子宫内接触阿片类药物的婴儿的不良神经发育结局。
Early Hum Dev. 2008 Jan;84(1):29-35. doi: 10.1016/j.earlhumdev.2007.01.013. Epub 2007 Aug 28.
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Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother.一位服用可待因母亲的母乳喂养新生儿吗啡中毒的药物遗传学
Lancet. 2006 Aug 19;368(9536):704. doi: 10.1016/S0140-6736(06)69255-6.
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Neonatal drug withdrawal. American Academy of Pediatrics Committee on Drugs.
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Neonatal abstinence syndrome due to codeine.可待因所致新生儿戒断综合征
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Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring.母亲药物滥用与后代随后发生婴儿猝死综合征的关系。
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Neonatal codeine withdrawal in infants of nonaddicted mothers.非成瘾母亲婴儿的新生儿可待因戒断反应
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Narcotic withdrawal reaction in a newborn infant due to codeine.一名新生儿因可待因而出现的麻醉药戒断反应。
Pediatrics. 1965 Oct;36(4):635-6.
9
Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man.人体中可待因和右美沙芬O-去甲基化和N-去甲基化的胎儿发育差异
Br J Clin Pharmacol. 1991 Sep;32(3):295-302. doi: 10.1111/j.1365-2125.1991.tb03902.x.
10
Infants and young children metabolise codeine to morphine. A study after single and repeated rectal administration.婴幼儿可将可待因代谢为吗啡。单次及重复直肠给药后的一项研究。
Br J Clin Pharmacol. 1992 Jan;33(1):45-9. doi: 10.1111/j.1365-2125.1992.tb03999.x.

母亲使用可待因导致的新生儿戒断综合征

Neonatal withdrawal syndrome due to maternal codeine use.

作者信息

Nair Vrinda, Soraisham Amuchou Singh, Akierman Albert

机构信息

Department of Pediatrics, Division of Neonatology, Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta.

出版信息

Paediatr Child Health. 2012 May;17(5):e40-1. doi: 10.1093/pch/17.5.e40.

DOI:10.1093/pch/17.5.e40
PMID:23633904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3381925/
Abstract

Neonatal withdrawal from maternal drugs and medications is not uncommon. Codeine-containing analgesic preparations given to pregnant mothers for headache have been identified as a cause of neonatal withdrawal syndrome. The present case highlights the importance of obtaining a detailed maternal drug history including prescription and nonprescription drugs, and highlights the need for prenatal counselling for women who are taking narcotic-containing analgesics.

摘要

新生儿从母体药物和药剂中戒断并不罕见。给怀孕母亲用于治疗头痛的含可待因镇痛制剂已被确认为新生儿戒断综合征的一个病因。本病例突出了获取包括处方药和非处方药在内的详细母亲用药史的重要性,并突出了对服用含麻醉剂镇痛剂的女性进行产前咨询的必要性。