解读长城/蛋白磷酸酶2A通路在细胞周期调控中的新作用
Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control.
作者信息
Lorca Thierry, Castro Anna
机构信息
Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoléculaire, CNRS UMR, Montpellier, France.
出版信息
Genes Cancer. 2012 Nov;3(11-12):712-20. doi: 10.1177/1947601912473478.
Abstract
Mitotic division is induced by protein phosphorylation. For a long time the supported hypothesis was that mitotic entry and exit were the exclusive result of cyclin B-Cdk1 kinase activation and inactivation, whereas the phosphatase activity required to dephosphorylate mitotic substrates was thought to be constant during mitosis. Recent data demonstrate that phosphatase activity must also be tightly regulated to promote correct cell division. Here we describe the new pathway involved in phosphatase regulation and the questions that this discovery raises concerning the classic view of cell cycle regulation.
摘要
有丝分裂由蛋白质磷酸化诱导。长期以来，支持的假说是有丝分裂的进入和退出是细胞周期蛋白B-Cdk1激酶激活和失活的唯一结果，而使有丝分裂底物去磷酸化所需的磷酸酶活性在有丝分裂期间被认为是恒定的。最近的数据表明，磷酸酶活性也必须受到严格调控以促进正确的细胞分裂。在这里，我们描述了参与磷酸酶调控的新途径以及这一发现对细胞周期调控经典观点提出的问题。
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