Deakin Julia, Lennox Belinda
Department of Psychiatry, Unversity of Cambridge, Cambridge UK.
Practitioner. 2013 Mar;257(1759):25-8, 3.
There is a worse prognosis for psychosis and schizophrenia when onset is in childhood or adolescence. However, outcomes are improved with early detection and treatment. Psychotic symptoms can be associated with a variety of disorders including schizophrenia, schizoaffective disorder, drug-induced psychosis, personality disorder, epilepsy and autistic spectrum disorder. Positive symptoms include hallucinations and delusions. Negative symptoms include apathy, lack of drive, poverty of speech, social withdrawal and self-neglect. The DSM IV criteria for schizophrenia include two or more of the following: hallucinations, delusions, disorganised speech, grossly disorganised or catatonic behaviour and negative symptoms. Adults may raise concerns about social withdrawal, bizarre ideas, a change in behaviour or a decline in achievement. Most children and young people with psychotic symptoms will not go on to develop psychosis or schizophrenia. Direct enquiry may be needed to elicit suspected unusual beliefs or hallucinations. To distinguish unusual ideas from delusions the ideas should be tested for fixity. For example by asking: 'Are you sure? Could there be another explanation?' Mood and anxiety symptoms should be explored. The assessment should include a developmental history with particular attention to premorbid functioning. Failure to make expected progress whether personal, social or academic is significant. Better outcomes in terms of symptoms and social function are associated with a shorter duration of untreated psychosis. The detection of psychotic symptoms in primary care therefore warrants an urgent referral to secondary care mental health services for assessment and treatment.
如果在儿童期或青少年期发病,精神病和精神分裂症的预后会更差。然而,早期发现和治疗可改善预后。精神病性症状可能与多种疾病相关,包括精神分裂症、分裂情感性障碍、药物所致精神病、人格障碍、癫痫和自闭症谱系障碍。阳性症状包括幻觉和妄想。阴性症状包括冷漠、缺乏动力、言语贫乏、社交退缩和自我忽视。精神分裂症的《精神疾病诊断与统计手册》第四版标准包括以下两项或更多:幻觉、妄想、言语紊乱、明显紊乱或紧张症行为以及阴性症状。成年人可能会对社交退缩、怪异想法、行为改变或成绩下降表示担忧。大多数有精神病性症状的儿童和年轻人不会发展为精神病或精神分裂症。可能需要直接询问以引出可疑的异常信念或幻觉。为了将异常想法与妄想区分开来,应对这些想法进行固定性测试。例如问:“你确定吗?会不会有其他解释?”应探究情绪和焦虑症状。评估应包括发育史,尤其要关注病前功能。在个人、社交或学业方面未能取得预期进展很重要。症状和社会功能方面更好的预后与未治疗的精神病持续时间较短有关。因此,在初级保健中发现精神病性症状需要紧急转诊至二级保健心理健康服务机构进行评估和治疗。