Department of Clinical Science and Biotechnology, Rheumatology Unit, University of L'Aquila, L'Aquila, Italy.
Expert Rev Clin Immunol. 2013 May;9(5):441-52. doi: 10.1586/eci.13.26.
Bariatric surgery represents a common approach for the control of severe morbid obesity, reducing caloric intake by modifying the anatomy of the gastrointestinal tract. Following jejunoileal bypass, a large spectrum of complications has been described, with rheumatic manifestation present in up to 20% of cases. Although bowel bypass syndrome, also called blind loop syndrome, is a well-recognized complication of jejunoileal bypass, the same syndrome was recognized in patients who had not had intestinal bypass surgery, and the term the 'bowel-associated dermatosis-arthritis syndrome' (BADAS) was coined. The pathogenesis of BADAS is as yet poorly understood and only few data concerning this issue have been published in the literature. The aim of the present paper is to review the literature and to discuss putative pathogenic mechanisms of BADAS, focusing on the immune system.
减重手术是控制严重病态肥胖的常用方法，通过改变胃肠道解剖结构来减少热量摄入。空肠回肠旁路术后，已经描述了一系列广泛的并发症，高达 20%的病例存在风湿表现。虽然肠旁路综合征，也称为盲袢综合征，是空肠回肠旁路的一种公认并发症，但在没有进行肠道旁路手术的患者中也发现了同样的综合征，因此提出了“肠道相关皮肤病关节炎综合征（BADAS）”这一术语。BADAS 的发病机制目前尚不清楚，文献中仅发表了一些关于这个问题的有限数据。本文的目的是回顾文献并讨论 BADAS 的可能发病机制，重点关注免疫系统。
