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肠道相关皮肤病-关节炎综合征(BADAS):一篇叙述性综述。

Bowel-associated dermatosis-arthritis syndrome (BADAS): a narrative review.

作者信息

Czajkowski Rafał, Lipska Patrycja, Watoła Wiktoria, Grabowska Nicole, Wełniak Adam

机构信息

Department of Dermatology and Venerology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Students' Scientific Club of Dermatology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

出版信息

Postepy Dermatol Alergol. 2023 Jun;40(3):355-361. doi: 10.5114/ada.2023.129101. Epub 2023 Jul 15.

Abstract

Bowel-associated dermatosis-arthritis syndrome is a neutrophilic dermatosis presenting with flu-like symptoms, arthritis and skin lesions. The type of skin presentation varies although typically consists of red patches progressing into papulopustular-type lesions. Initially, the pathogenesis of the disease was linked exclusively to bariatric surgery, but more recent reports indicate the role of gastrointestinal diseases resulting in bacterial overgrowth and consequent translocation of bacteria into the bloodstream. The disease may resolve spontaneously, however sometimes requires a treatment aimed at managing inflammation and excessive bacterial overgrowth, and therefore antibiotic therapy, immunosuppressive drugs, biological treatment and sometimes intestinal surgeries are applied.

摘要

肠道相关皮肤病-关节炎综合征是一种中性粒细胞性皮肤病,表现为流感样症状、关节炎和皮肤病变。皮肤表现类型各异,不过通常由红色斑块发展为丘疹脓疱型病变。最初,该病的发病机制仅与减肥手术有关,但最近的报告表明,胃肠道疾病导致细菌过度生长以及随后细菌转移至血液中的作用。该病可能会自行缓解,然而有时需要进行旨在控制炎症和过度细菌生长的治疗,因此会应用抗生素治疗、免疫抑制药物、生物治疗,有时还会进行肠道手术。

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