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儿童青少年特发性关节炎的软骨骨损伤。

Osteochondral lesions in children with juvenile idiopathic arthritis.

机构信息

Department of Paediatrics, Kuopio University Hospital, Kuopio FIN-70211, Finland.

出版信息

Pediatr Rheumatol Online J. 2013 May 1;11(1):18. doi: 10.1186/1546-0096-11-18.

Abstract

BACKGROUND

Joint pain and swelling are typical symptoms in children with juvenile idiopathic arthritis (JIA) and these are often related to inflammation of the joint. Juvenile osteochondritis dissecans (JOCD), that is separation of a bone-cartilage segment from the articular surface, can manifest with similar symptoms.

FINDINGS

We studied thirteen cases of osteochondritis dissecans lesions (OCD) in children with JIA. There were nine girls and four boys with a mean age of 6.5 (2-12) years at the time of diagnosis of JIA. Mean time between diagnosis of JIA and manifestation of OCD was 5.5 (1-11) years. Indications for MRI were the presence of pain or discomfort in the joint, despite otherwise effective treatment, with no evidence from ultrasound examination of any obvious signs of active inflammation. The most common location of osteochondral lesion was the knee, although the ankle joint was affected in one case. Five patients had lesions in both knees. Operative treatment was needed in eight cases (joints).

CONCLUSIONS

Pain, and minor dysfunction of the joint are common complaints of children suffering from JIA. Earlier research has discounted the possibility of children who were not athletes presenting with this condition. However, this study demonstrates that these lesions also seem to be relatively common in patients with JIA. When there is no sign of inflammation, the possibility of OCD must therefore be considered in these children.

摘要

背景

关节疼痛和肿胀是幼年特发性关节炎(JIA)患儿的典型症状,这些通常与关节炎症有关。青少年剥脱性骨软骨炎(JOCD),即骨-软骨段从关节表面分离,也可能表现出类似的症状。

结果

我们研究了 13 例 JIA 患儿的剥脱性骨软骨炎(OCD)病变。9 例为女孩,4 例为男孩,JIA 诊断时的平均年龄为 6.5(2-12)岁。JIA 诊断与 OCD 表现之间的平均时间为 5.5(1-11)年。MRI 的指征是关节存在疼痛或不适,尽管经超声检查未发现明显的活动性炎症迹象,但经治疗后仍未缓解。最常见的骨软骨病变部位是膝关节,但踝关节也有一例受累。5 例患者双膝均有病变。8 例(关节)需要手术治疗。

结论

疼痛和关节轻微功能障碍是 JIA 患儿常见的主诉。早期研究排除了非运动员儿童出现这种情况的可能性。然而,本研究表明,这些病变在 JIA 患者中似乎也较为常见。因此,当没有炎症迹象时,必须考虑这些儿童存在 OCD 的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e921/3648357/04e8c81f0cff/1546-0096-11-18-1.jpg

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