钯催化的通过 C-H 键活化的 2-溴二芳基砜的分子内直接芳基化反应。
Palladium-catalyzed intramolecular direct arylation of 2-bromo-diaryl sulfoxides via C-H bond activation.
机构信息
Laboratoire de Synthèse et Catalyse Asymétrique (SynCat), Université de Strasbourg (ECPM) , UMR CNRS 7509, 25 rue Becquerel, 67087 Strasbourg Cedex 02, France.
出版信息
Org Lett. 2013 May 17;15(10):2490-3. doi: 10.1021/ol400966q. Epub 2013 May 2.
PMID:23635077
Abstract
Efficient access to dibenzothiophene-S-oxides from differently substituted 2-bromo-diarylsulfinyl moieties using ligandless Pd(OAc)2 as the catalyst and KOAc as the base in dimethylacetamide at 130 °C is reported. Various dibenzothiophene-S-oxides were obtained in excellent yields.
摘要
报道了一种使用无配体 Pd(OAc)2 作为催化剂和 KOAc 作为碱，在二甲基乙酰胺中于 130°C 下从不同取代的 2-溴二芳基亚砜基制备二苯并噻吩-S-氧化物的方法。各种二苯并噻吩-S-氧化物都以优异的收率得到。
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